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MetabolomicsMyeloid PFKFB3-mediated glycolysis promotes kidney fibrosis
Excessive renal fibrosis is a common pathology in progressive chronic kidney diseases. Inflammatory injury and aberrant repair processes contribute to the development of kidney fibrosis. Myeloid cells, particularly monocytes/macrophages, play a crucial role in kidney fibrosis by releasing their proi...
2024-03-12 | MTBLS8278 | MetaboLights
ProteomicsProteomic characterization of human multiple myeloma bone marrow
Glavey SV, Naba A, Manier S, Clauser KR, Tahri S, Park J, Reagan MR, Moschetta M, Mishima Y, Gambella M, Rocci A, Sacco A, Asara JM, Palumbo A, Roccaro AM, Hynes RO, Ghobrial IM. The extracellular matrix (ECM) is a major component of the tumor microenvironment, contributing to the regulation of cell...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-01-06 | MSV000080451 | MassIVE
MetabolomicsPFKFB3-mediated glycolysis boosts fibroblast activation and subsequent kidney fibrosis

Renal fibrosis, a hallmark of chronic kidney diseases, is driven by the activation of renal fibroblasts. Recent studies have highlighted the role of glycolysis in this process. Nevertheless, one critical glycolytic activator, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), remain...

2024-03-12 | MTBLS8281 | MetaboLights
MetabolomicsClock regulation of metabolites reveals coupling between transcription and metabolism
The circadian clock is intricately connected with metabolism, however the precise details of these connections are incomplete. Here we used high temporal resolution metabolite profiling to determine circadian regulation of mouse liver and cell autonomous metabolism. In mouse liver, we found ~50% of ...
2017-04-05 | MTBLS292 | MetaboLights
ProteomicsAge-induced methylmalonic acid accumulation promotes cancer aggressiveness and metastatic disease
TMT protein abundance profiling of human serum from 30 young and 30 older adults.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-02-18 | MSV000084974 | MassIVE
UnknownTransaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma.
Not available
S-EPMC6219629 | biostudies-literature
UnknownHarmonizing lipidomics: NIST interlaboratory comparison exercise for lipidomics using SRM 1950-Metabolites in Frozen Human Plasma.
Not available
S-EPMC5711491 | biostudies-literature
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