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TranscriptomicsASCC3 promotes chemosensitivity in colorectal cancer cells
The activating signal co-integrator 1 complex subunit 3 (ASCC3), a multifunctional protein, has been implicated as a prognostic marker in several types of cancer. However, mechanisms underlying its prognostic value are not fully understood. Here, we report that ASCC3 promotes sensitivity to chemothe...
ORGANISM(S): Homo sapiens 
2025-11-15 | E-MTAB-15818 | biostudies-arrayexpress
GenomicsASCC3 promotes chemosensitivity in colorectal cancer cells
ASCC3 promotes chemosensitivity in colorectal cancer cells
PRJEB101285 | ENA
TranscriptomicsmRNA sequencing identifies differential gene expresssion profiles between ASCC3 knock-down cells and control cells
We sequenced mRNAs from HeLa cells transduced with either scrambled shRNA or shRNA targeting ASCC3. The results have shown differential gene expression in ASCC3 knockdown cells, suggesting a regulatory role for ASCC3 in certain cellular pathway. mRNA from HeLa cells transduced with either scrambled ...
ORGANISM(S): Homo sapiens 
2013-06-15 | E-GEOD-47399 | biostudies-arrayexpress
ProteomicsCRISPR activation of the ribosome-associated quality control factor ASCC3 ameliorates fragile X syndrome phenotypes in mice
Loss of fragile X messenger ribonucleoprotein (FMRP) causes fragile X syndrome (FXS), an inherited neurodevelopmental disorder resulting in intellectual disability and autism-spectrum disorder. Despite the prevalence of the FXS, the molecular function of FMRP remains uncertain. Here, we showed that...
ORGANISM(S): Homo sapiens (Human) 
2026-04-20 | PXD067852 | Pride
Hek293t 
TranscriptomicsmRNA sequencing identifies differential gene expresssion profiles between ASCC3 knock-down cells and control cells
We sequenced mRNAs from HeLa cells transduced with either scrambled shRNA or shRNA targeting ASCC3. The results have shown differential gene expression in ASCC3 knockdown cells, suggesting a regulatory role for ASCC3 in certain cellular pathway.
ORGANISM(S): Homo sapiens 
2013-06-15 | GSE47399 | GEO
UnknownThe Ski2 helicase ASCC3 unwinds DNA upon fork stalling to control replication stress responses.
Not available
S-EPMC12330601 | biostudies-literature
UnknownThe interaction of DNA repair factors ASCC2 and ASCC3 is affected by somatic cancer mutations.
Not available
S-EPMC7608686 | biostudies-literature
TranscriptomicsIllumina bead array -/+ UV ASCC3 short isoform knockout cells
The transcription-related DNA damage response was analyzed on a genome-wide scale with great spatial and temporal resolution. Upon UV irradiation, a slowdown of transcript elongation and restriction of gene activity to the promoter-proximal ~25 kilobases is observed. This is associated with a shift ...
ORGANISM(S): Homo sapiens 
2017-02-21 | GSE92325 | GEO
TranscriptomicsIllumina bead array -/+ UV ASCC3 long isoform shRNA knockdown cells
The transcription-related DNA damage response was analyzed on a genome-wide scale with great spatial and temporal resolution. Upon UV irradiation, a slowdown of transcript elongation and restriction of gene activity to the promoter-proximal ~25 kilobases is observed. This is associated with a shift ...
ORGANISM(S): Homo sapiens 
2017-02-21 | GSE92327 | GEO
UnknownDiscovery of a neuromuscular syndrome caused by biallelic variants in ASCC3.
Not available
S-EPMC8756546 | biostudies-literature
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