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ProteomicsASGR1 deficiency diverts lipids toward adipose tissue but results in liver damage during obesity.
Asialoglycoprotein receptor 1 (ASGR1), primarily expressed on hepatocytes, promotes the clearance and the degradation of glycoproteins, including lipoproteins, from the circulation. In humans, loss-of-function variants of ASGR1 are associated with a favorable metabolic profile and reduced incidence ...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-29 | PXD046809 | Pride
Adipose tissue Liver Asgr1 Shotgun proteomics 
GenomicsHypomorphic ASGR1 Modulates Lipid Homeostasis via SREBPs Network
Hypomorphic ASGR1 Modulates Lipid Homeostasis via SREBPs Network
PRJNA738702 | ENA
ProteomicsAsialoglycoprotein receptor subunit ASGR1a deficiency leads to cholesterol malabsorption in zebrafish on a high cholesterol diet
One of the major pathways to clear glycoproteins from circulation is via the liver-specific asialoglycoprotein receptor (ASGPR). Recently, loss of asialoglycoprotein receptor 1 (ASGR1), the major subunit of ASGPR in humans, was found to correlate with lower levels of plasma apolipoprotein B-containi...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2026-09-07 | PXD078307 | Pride
Asgr1 Steatosis Cholesterol Liver Zebrafish 
TranscriptomicsHypomorphic ASGR1 Modulates Lipid Homeostasis via SREBPs Network
A population genetic study identified that the asialoglycoprotein receptor 1 (ASGR1) mutation carriers had significantly lower non-HDL-c levels and reduced risks of cardiovascular diseases. However, the mechanism behind this phenomenon remained unclear. Here, we established Asgr1 knockout mice that ...
ORGANISM(S): Mus musculus 
2021-12-31 | GSE178370 | GEO
GenomicsASGR1 Is a Promising Target for Lipid Reduction in Pigs with PON2 As Its Inhibitor
ASGR1 Is a Promising Target for Lipid Reduction in Pigs with PON2 As Its Inhibitor
PRJNA1119453 | ENA
TranscriptomicsASGR1 Is a Promising Target for Lipid Reduction in Pigs with PON2 As Its Inhibitor
Although the role of asialoglycoprotein receptor 1 (ASGR1) in lowering lipid levels is well established, recent studies indicate that ASGR1 inhibition can cause unexpected liver damage in pigs, raising a serious issue about whether ASGR1 can be a good target for treating ASCVD. Here, we utilized the...
ORGANISM(S): Sus scrofa 
2024-08-16 | GSE268910 | GEO
TranscriptomicsDeficiency of ASGR1 promotes liver injury by increasing GP73-mediated hepatic endoplasmic reticulum stress
Liver injury is a core pathological process in the majority of liver diseases, yet the genetic factors predisposing individuals to its initiation and progression remain poorly understood. Here we show that asialoglycoprotein receptor 1 (ASGR1), a lectin specifically expressed in the liver, is downre...
ORGANISM(S): Mus musculus 
2023-11-26 | GSE232677 | GEO
UnknownASGR1 and Its Enigmatic Relative, CLEC10A.
Not available
S-EPMC7404283 | biostudies-literature
GenomicsNext Generation Sequencing Facilitates Transcriptomes Quantitative Analysis of siRNA mediated ASGR1 knockdown
Next Generation Sequencing Facilitates Transcriptomes Quantitative Analysis of siRNA mediated ASGR1 knockdown
PRJNA758812 | ENA
UnknownHypomorphic ASGR1 modulates lipid homeostasis via INSIG1-mediated SREBP signaling suppression.
Not available
S-EPMC8525641 | biostudies-literature
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