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MetabolomicsAftpo3 and Afdur3, the Aspergillus fumigatus Plasma Membrane Transporters of Polyamines, Regulate Polyamine Homeostasis and Itraconazole Susceptibility

Aspergillus fumigatus is a notorious opportunistic pathogen that causes Invasive Aspergillosis (IA) infections with high mortality in immunosuppressed individuals. Long-term antifungal drug azole abuse in clinical treatment and agriculture renders it ineffectual or drug resistant. Drug resistance...

2020-12-21 | MTBLS1739 | MetaboLights
MetabolomicsDeletion of Gliotoxin Biosynthesis Remodels the Intra- and Extracellular Metabolic Status of Aspergillus fumigatus, Alters Its Virulence-Related Phenotypes, and Modulates Host Immune Responses_Mycelium

Gliotoxin is a secondary metabolite produced by Aspergillus fumigatus, known to play a significant role in immune regulation and virulence phenotypes. This study investigates how the deletion of gliotoxin biosynthesis remodels the metabolic state of A. fumigatus and subsequently af...

2026-05-11 | MTBLS14012 | MetaboLights
MetabolomicsDeletion of Gliotoxin Biosynthesis Remodels the Intra- and Extracellular Metabolic Status of Aspergillus fumigatus, Alters Its Virulence-Related Phenotypes, and Modulates Host Immune Responses_culture supernatant

Gliotoxin is a secondary metabolite produced by Aspergillus fumigatus, known to play a significant role in immune regulation and virulence phenotypes. This study investigates how the deletion of gliotoxin biosynthesis remodels the metabolic state of A. fumigatus and subsequently af...

2026-05-11 | MTBLS14011 | MetaboLights
TranscriptomicsEffect of amphotericin B on Aspergillus fumigatus
Amphotericin B (AMB) is the most widely used polyene antifungal drug for the treatment of systemic fungal infections including invasive aspergillosis. We aimed to understand molecular targets of AMB in Aspergillus fumigatus (Afu) by genomic approaches. Amphotericin B (AMB) is the most widely used p...
ORGANISM(S): Aspergillus fumigatus 
2010-05-26 | E-GEOD-10505 | biostudies-arrayexpress
TranscriptomicsFunctional genomics of Aspergillus fumigatus conidiospores interacting with human bronchial epithelial cells
The cells of the airway epithelium play critical roles in host defense to inhaled irritants, and in asthma pathogenesis. These cells are constantly exposed to conidiospores of the ubiquitous mould Aspergillus fumigatus, which are small enough to reach the alveoli. This exposure is asymptomatic in mo...
ORGANISM(S): Aspergillus fumigatus 
2011-06-01 | E-GEOD-16630 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of ATCC46645 strain and isogenic M-NM-^TpacC Aspergillus fumigatus mutant during murine infection
In lung diseases caused by the major mould pathogen Aspergillus fumigatus the pulmonary epithelium is destroyed by invasive growth of fungal hyphae, a process thought to require fungal proteases. Here we show that the A. fumigatus pH-responsive transcription factor PacC governs expression of secrete...
ORGANISM(S): Aspergillus fumigatus 
2014-10-20 | E-GEOD-54810 | biostudies-arrayexpress
TranscriptomicsEffect of Artemisinin on Aspergillus fumigatus gene expression program
We examined the antifungal activity of artemisinin against Aspergillus fumigatus (A. fumigatus), a pathogenic filamentous fungus responsible for allergic and invasive aspergillosis in humans and analyzed transcript profiles of the fungus on exposure to Artemisinin. A. fumigatus spores were cultured ...
ORGANISM(S): Aspergillus fumigatus 
2011-05-11 | E-GEOD-21297 | biostudies-arrayexpress
TranscriptomicsFunctional genomics of human bronchial epithelial cells interacting with conidiospores of Aspergillus fumigatus
The cells of the airway epithelium play critical roles in host defense to inhaled irritants, and in asthma pathogenesis. These cells are constantly exposed to conidiospores of the ubiquitous mould Aspergillus fumigatus, which are small enough to reach the alveoli. This exposure is asymptomatic in mo...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-16628 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis of interactions between Aspergillus fumigatus conidiospores and human bronchial epithelial cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Aspergillus fumigatus 
2011-06-01 | E-GEOD-16637 | biostudies-arrayexpress
TranscriptomicsAspergillus fumigatus Af293 response to lactic acid bacteria antifungal activity
The effect of cell free supernatant from the antifungal strain Lactobacillus plantarum 16 on the growth of Aspergillus fumigatus Af293 was assessed. Transcriptome analysis of the genome was performed after ten minutes exposure to antifungal supernatant in order to determine the molecular targets inv...
ORGANISM(S): Aspergillus fumigatus 
2013-08-09 | E-MTAB-1701 | biostudies-arrayexpress
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