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GenomicsComparative genome-wide DNA methylation analysis of colorectal tumor and matched normal tissues
In our study we applied a genome-wide DNA methylation analysis approach, MethylCap-seq, to map the differentially methylated regions in 24 tumor and matched normal colon samples. In total, 2687 frequently hypermethylated and 468 frequently hypomethylated regions were identified, which include potent...
ORGANISM(S): Homo sapiens 
2012-10-26 | E-GEOD-39068 | biostudies-arrayexpress
TranscriptomicsA promoter DNA demethylation landscape of human hematopoietic differentiation
Global mechanisms defining the gene expression programs specific for hematopoiesis are still not fully understood. Here, we show that promoter DNA demethylation is associated the activation of hematopoietic-specific genes. Using genome-wide promoter methylation arrays, we identified 694 hematopoie...
ORGANISM(S): Homo sapiens 
2011-09-14 | E-GEOD-30090 | biostudies-arrayexpress
Genomicsena-DATASET-DKFZ-Epigenomics-19-11-2015-09:37:32:058-207 - samples
RNA-seq of peripheral blood samples from CLL patients.
EGAD00001001675 | EGA
Genomicsena-DATASET-DKFZ-Epigenomics-19-11-2015-09:41:10:900-208 - samples
Tagmentation-based whole-genome bisulfite sequencing of isolated cell types from healthy controls.
EGAD00001001676 | EGA
Genomics450K_DKFZ_CLL_NB
CLL and normal B cell samples using 450K
EGAD00010000871 | EGA
GenomicsAnalysis of DNA methylation in normal B cells and chronic lymphocytic leukemia
Charting differences between tumors and normal tissue is a mainstay of cancer research. However, clonal tumor expansion from complex normal tissue architectures potentially obscures cancer-specific events, including divergent epigenetic patterns. Using whole-genome bisulfite sequencing of normal B c...
EGAS00001000534 | EGA
GenomicsData Access Committee of DKFZ-Epigenomics
Data Access Committee EGAC00001000279
EGAC00001000279 | EGA
Genomicsena-DATASET-UKEssen-09-09-2015-10:54:33:815-144 - samples
In this dataset, 16 trios- primary tumor, relapse and corresponding normals- for patients with neuroblastoma are provided. For one patient, more than one relapse was available for the analyses.
EGAD00001001607 | EGA
GenomicsGenomes of Relapsing Neuroblastoma
Neuroblastoma is a malignancy of the developing sympathetic nervous system that is often lethal when relapse occurs, but the molecular mechanisms behind this process are poorly defined. We here used whole-exome sequencing, mRNA expression, array CGH and DNA methylation analysis to holistically chara...
EGAS00001001387 | EGA
GenomicsRelapsed and Primary Neuroblastoma DAC
Data Access Committee EGAC00001000373
EGAC00001000373 | EGA
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