Comparative genome-wide DNA methylation analysis of colorectal tumor and matched normal tissues

ABSTRACT: In our study we applied a genome-wide DNA methylation analysis approach, MethylCap-seq, to map the differentially methylated regions in 24 tumor and matched normal colon samples. In total, 2687 frequently hypermethylated and 468 frequently hypomethylated regions were identified, which include potential biomarkers for CRC diagnosis. Hypermethylation in the tumor samples was enriched at CpG islands and gene promoters, while hypomethylation was distributed throughout the genome. Using epigenetic data from human embryonic stem cells, we show that frequent differentially methylated regions (DMRs) coincide with bivalent loci in human embryonic stem cells. DNA methylation is commonly thought to lead to cancer gene related silencing, however integration of publically available expression analysis

ORGANISM(S): Homo sapiens

SUBMITTER: Arjen Brinkman 

PROVIDER: E-GEOD-39068 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress