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GenomicsDiscovery of Transcription Factors and Regulatory Regions Driving In Vivo Tumor Development by ATAC-seq and FAIRE-seq Open Chromatin Profiling
Genomic enhancers regulate spatio-temporal gene expression by recruiting specific combinations of transcription factors (TFs). When TFs are bound to active regulatory regions, they displace canonical nucleosomes, making these regions biochemically detectable as nucleosome-depleted regions or accessi...
ORGANISM(S): Drosophila melanogaster 
2015-02-13 | E-GEOD-59078 | biostudies-arrayexpress
TranscriptomicsTime series ATAC-seq of Th1 differentiation: The effect of Progesterone on Th1 differentiation?
T-helper 1 responses are involved in the development of many autoimmune diseases such as Multiple sclerosis (MS). MS is a relapse remitting disease that eventually progresses to a progressive neurodegenerative disease. During pregnancy the relapse rate of MS is significantly reduced with peak reduct...
ORGANISM(S): Homo sapiens 
2021-09-09 | E-MTAB-10444 | biostudies-arrayexpress
TranscriptomicsATAC-seq of HepG2 cells
ATAC-seq open chromatin maps for HepG2 cells (3 biological replicates), a liver model.
ORGANISM(S): Homo sapiens 
2019-03-20 | E-MTAB-7543 | biostudies-arrayexpress
TranscriptomicsATAC-seq of oesophageal adenocarcinoma cell line MFD-1
The open chromatin of new esophageal adenocarcinoma cell line MFD-1 has been profiled by ATAC-seq.
ORGANISM(S): Homo sapiens 
2018-04-06 | E-MTAB-6720 | biostudies-arrayexpress
TranscriptomicsATAC-seq of iPSC and human dermal fibroblasts
ATAC-seq of iPSC and human dermal fibroblasts, used to compare open chromatin and transcription signal.
ORGANISM(S): Homo sapiens 
2021-05-02 | E-MTAB-10381 | biostudies-arrayexpress
TranscriptomicsAssay for Transposase-Accessible Chromatin sequencing (ATAC-seq) of primary melanocytes from five human donors
ATAC-seq was conducted to map open chromatin regions in five individual primary human melanocyte cultures. The ATAC libraries were sequenced using paired-end sequencing on an Illumina NovaSeq platform. In total, we sequenced 15 ATAC libraries from these five independent primary melanocyte cultures (...
ORGANISM(S): Homo sapiens 
2025-04-24 | E-MTAB-15048 | biostudies-arrayexpress
TranscriptomicsATAC-seq for Linear RAG Scanning Mediates Editing of Igκ Variable Region Repertoires
We performed ATAC-seq in v-Abl transformed pro-B cells and its various mutant derivatives to study the differential molecular mechanisms of Igk secondary V(D)J recombination.
ORGANISM(S): Mus musculus 
2026-02-23 | E-MTAB-16602 | biostudies-arrayexpress
TranscriptomicsATAC-Seq using native and iPSC-derived murine retina at three developmental stages.
To identify epigenetic programs underlying differentiation of mouse retina, we performed ATAC-Seq on bulk native retina (NaR) and iPSC-derived 3D retinal aggregates (3D-RA) at three matched stages of development: embryonic day (E)13 vs differentiation day (DD)13, postnatal day (P)0 vs DD21, and P5 v...
ORGANISM(S): Mus musculus 
2021-06-30 | E-MTAB-9440 | biostudies-arrayexpress
TranscriptomicsATAC-seq of HEK293T cell line
An enhancer of chr8 (chr8:579137-581436) was deleted using CRISPR and the effects of its deletion were assessed using ATAC-seq
ORGANISM(S): Homo sapiens 
2017-08-01 | E-MTAB-5702 | biostudies-arrayexpress
TranscriptomicsATAC-seq of primary mesenchymal stem cell (MSC)-derived osteoblasts (differentiated with BMP2) from 4 human donors
ATAC-seq was performed to map open chromatin regions in hMSC-derived osteoblasts
ORGANISM(S): Homo sapiens 
2019-03-20 | E-MTAB-6834 | biostudies-arrayexpress
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