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ProteomicsIncreased expression of ATase1/NAT8B or ATase2/NAT8 in the mouse results in an autistic-like phenotype with altered dendritic branching and spine formation
Neurons heavily depend on the ability of the secretory pathway to deliver correctly folded polypeptides to the periphery of the cell for the assembly, maintenance, and normal functioning of synapses. The endoplasmic reticulum (ER) acetylation machinery has emerged as a novel branch of the more gener...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-31 | PXD051786 | Pride
Lysine acetylation Autism spectrum disease Atase1 Atase2 
UnknownOverexpression of ATase1 and ATase2 disrupts the secretome and causes a progeria phenotype.
Not available
S-EPMC12423556 | biostudies-literature
UnknownEndoplasmic reticulum acetyltransferases Atase1 and Atase2 differentially regulate reticulophagy, macroautophagy and cellular acetyl-CoA metabolism.
Not available
S-EPMC8041774 | biostudies-literature
ProteomicsAtase1 and Atase2 differentially regulate reticulophagy and cellular acetyl-CoA metabolism
Acetylation stoichiometry analysis of ER-enriched samples from knockout ATase1 and ATase2 mice.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-01-17 | MSV000086712 | MassIVE
UnknownThe endoplasmic reticulum acetyltransferases ATase1/NAT8B and ATase2/NAT8 are differentially regulated to adjust engagement of the secretory pathway.
Not available
S-EPMC7363514 | biostudies-literature
UnknownIncreased expression of ATase1/NAT8B or ATase2/NAT8 in the mouse results in an autistic-like phenotype with altered dendritic branching and spine formation.
Not available
S-EPMC12700795 | biostudies-literature
UnknownThe endoplasmic reticulum-based acetyltransferases, ATase1 and ATase2, associate with the oligosaccharyltransferase to acetylate correctly folded polypeptides.
Not available
S-EPMC4231681 | biostudies-literature
ProteomicsOverexpression of ATase1 and ATase2 in the mouse disrupts the quality of the secretome and causes a progeria phenotype
Acetylation in the lumen of the endoplasmic reticulum requires two acetyltransferases, ATase1/NAT8B and ATase2/NAT8. They are type II membrane proteins and belong to the larger GNAT superfamily of acetyltransferases. Their enzymatic activity is tightly coupled to the import of acetyl-CoA in the lume...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2025-03-18 | MSV000097367 | MassIVE
UnknownImproved proteostasis in the secretory pathway rescues Alzheimer's disease in the mouse.
Not available
S-EPMC4805081 | biostudies-literature
UnknownTwo endoplasmic reticulum (ER)/ER Golgi intermediate compartment-based lysine acetyltransferases post-translationally regulate BACE1 levels.
Not available
S-EPMC2629114 | biostudies-literature
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