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GenomicsTranscriptional phenotype in a novel ataxin-3 knock-in mouse model for spinocerebellar ataxia type 3
Transcriptional phenotype in a novel ataxin-3 knock-in mouse model for spinocerebellar ataxia type 3
PRJNA607747 | ENA
TranscriptomicsTranscriptional phenotype in a novel ataxin-3 knock-in mouse model for spinocerebellar ataxia type 3
Spinocerebellar ataxia type 3 is the most common autosomal dominant inherited ataxia worldwide and caused by a CAG repeat expansion in the Ataxin-3 gene resulting in a polyQ expansion in the corresponding protein. The disease is characterized by neuropathological (aggregate formation, cell loss), ph...
ORGANISM(S): Mus musculus 
2022-04-01 | GSE145613 | GEO
UnknownPhysiological and pathophysiological characteristics of ataxin-3 isoforms.
Not available
S-EPMC6333899 | biostudies-literature
ProteomicsSodium valproate is protective in a transgenic zebrafish model of Machado Joseph disease
The neurodegenerative disease Machado Joseph disease (MJD, also known as spinocerebellar ataxia-3) is a fatal disease that impairs control and co-ordination of movement. MJD is caused by expansion of a trinucleotide (CAG) repeat region within the ATXN3 gene, encoding a long polyglutamine (polyQ) reg...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2021-08-23 | PXD009612 | Pride
Ataxin-3 Label-free quantitative proteomics Machado joseph disease Polyq Zebrafish 
UnknownConformational behavior and aggregation of ataxin-3 in SDS.
Not available
S-EPMC3718759 | biostudies-literature
UnknownMouse ataxin-3 functional knock-out model.
Not available
S-EPMC3044828 | biostudies-literature
UnknownA Robust Assay to Monitor Ataxin-3 Amyloid Fibril Assembly.
Not available
S-EPMC9222203 | biostudies-literature
UnknownAtaxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models.
Not available
S-EPMC4754714 | biostudies-literature
UnknownUbe2w and ataxin-3 coordinately regulate the ubiquitin ligase CHIP.
Not available
S-EPMC3166620 | biostudies-literature
UnknownAtaxin-3, The Spinocerebellar Ataxia Type 3 Neurodegenerative Disorder Protein, Affects Mast Cell Functions.
Not available
S-EPMC9086395 | biostudies-literature
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