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MetabolomicsMetabolomic determinants of carotid atherosclerosis plaque stability
Our objective is to identify the metabolites associated with stability of carotid atheromatous plaques compared to vulnerable plaques, through a metabolomic approach. Eighty consecutive patients with carotid artery stenosis (CAS) who underwent carotid endarterectomy (CEA) according to current guidel...
2025-06-06 | MTBLS12303 | MetaboLights
Transcriptomicsprofiles of microRNA expression of atherosclerotic plaques
To investigate the expression profiles of miRNA in atherosclerotic plaques, the global features of miRNAs expression of three normal coronary artery tissues sample pools and three sample pools of advanced atherosclerosis plaques of coronary artery were studied using microarray technology,
ORGANISM(S): Homo sapiens 
2015-02-20 | E-MTAB-2460 | biostudies-arrayexpress
Transcriptomicsmicroarray of human atherosclerotic plaques
The Total RNA from seven control pool and seven atherosclerotic plaque sample pools were labeled by Cy3/Cy5 respectively and analyzed on 22K human genome array chip V1.0.
ORGANISM(S): Homo sapiens 
2015-02-20 | E-MTAB-2458 | biostudies-arrayexpress
TranscriptomicsDNA methylation status of CpG islands in normal and atherosclerotic human arteries
Abnormal epigenetic gene regulation may play a pivotal role in atherogenesis. In particular, global DNA hypomethylation potentially leading to proatherogenic gene expression, occurs in atherosclerotic lesions in humans and animal models. In order to identify genomic sequences targeted for DNA hypome...
ORGANISM(S): Homo sapiens 
2010-06-20 | E-GEOD-15552 | biostudies-arrayexpress
ProteomicsAtherosclerotic environment effect over CAC pre-angiogenic role
In response to vascular injury, early EPC or Circulating angiogenic cells (CAC) are thought to be recruited to the damaged areas, participating mainly in a paracrine fashion, by releasing pro-angiogenic factors, promoting the mobilization of other cell populations such as the late EPC, or endothelia...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD019395 | Pride
Proteomics Angiogenesis Circulating angiogenic cells Atherosclerotic factors Paracrine role Endothelial colony forming cells Secretome 
TranscriptomicsCirculating Mononuclear Cell Transcriptomes in Patients with Atherosclerotic Coronary Artery Disease
Monocytes and T-cells play an important role in the development of atherosclerotic coronary artery disease (CAD). Differences in transcriptional activity of these cells might reflect the individual's atherosclerotic burden. Transcriptome analysis of circulating mononuclear cells from carefully match...
ORGANISM(S): Homo sapiens 
2008-12-01 | E-GEOD-9820 | biostudies-arrayexpress
ProteomicsLong-term changes following pre-conditioned circulating angiogenic cells therapy in critical limb ischemia
Critical limb ischemia (CLI), results from a severe blockade of the arterial vessels, is usually correlated to atherosclerosis. Circulating angiogenic cells (CACs) constitute a good alternative as CLI cell therapy due to their vascular regenerative potential, although the mechanisms of action of the...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-16 | PXD024132 | Pride
Neovascularization Circulating angiogenic cells Immune cells Atherosclerotic secretome Critical limb ischemia 
TranscriptomicsTranscription profiling of white adipose tissue from Lldlr-/- and Lldlr-/-Mif-/- mice
MIF deficiency reduces chronic inflammation in white adipose tissue and impairs development of insulin resistance, glucose intolerance and associated atherosclerotic disease
ORGANISM(S): Mus musculus 
2009-06-19 | E-TABM-524 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse offspring of crosses between hypercholesterolemic and normocholesterolemic parents LUMC-HKG-ApoE-Atherosclerosis
Enhanced prenatal fatty streak formation in human fetuses has been associated with maternal hypercholesterolemia. However, the possible roles of maternal genetic background and in utero environment on development of atherosclerosis in adult life have not been unraveled. We generated genetically iden...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6134 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of human atherosclerotic plaque
This SuperSeries is composed of the following subset Series: GSE23303: Gene expression profiling of human atherosclerotic plaque: Laser capture microscopy of smooth muscle cells and macrophages GSE23304: Gene expression profiling of human atherosclerotic plaque: 101 peripheral plaques GSE24495: Gene...
ORGANISM(S): Homo sapiens 
2011-09-30 | E-GEOD-23314 | biostudies-arrayexpress
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