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TranscriptomicsRNA-seq of choroid and retina in tree shrews with choroidal neovascularization
In order elucidate the key signaling pathways in choroidal neovascularization, we induced choroidal angiogenesis by laser photocoagulation in 12 tree shrews and obtained mRNA profiles of their choroids and retinas by high-throughput transcriptome sequencing. Gene ontology(GO) and kyoto encyclopedia ...
ORGANISM(S): Tupaia chinensis 
2021-03-21 | E-MTAB-10198 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiling In Murine Corneal Neovascularization Models
In order to find out the vital genes during the corneal neovascularization (CNV), we set up two CNV models, one being induced by suture placement and the other by alkali burn to the corneal center. Young adult Balb/c and C57BL/6 were used. The corneas were checked daily for CNV development and some ...
ORGANISM(S): Mus musculus 
2011-02-08 | E-GEOD-23347 | biostudies-arrayexpress
ProteomicsProteotranscriptomic Analyses in Laser-Induced Choroidal Neovascularization
To probe into the molecular mechanism underlying the onset of choroidal neovascularization (CNV), integrated transcriptomic and proteomic analyses of the retinas in mice with laser-induced CNV were performed by using RNA sequencing and tandem mass tag.
ORGANISM(S): Mus Musculus 
2023-02-09 | PXD039971 |
ProteomicsInsights into myopic choroidal neovascularization based on quantitative proteomics analysis of the aqueous humor
Previous studies on the biomarkers of pathologic myopia choroidal neovascularization (pmCNV) development merely detected limited types of proteins and provide a meagre illustration of the underlying pathways. Hence, an intact picture of molecular changes in the aqueous humor (AH) of pmCNV patients i...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD038430 | Pride
Proteomic  pathologic myopia  choroidal neovascularization  aqueous humor  gfap  biomarker. 
ProteomicsMonocyte histone lactylation-regulated exosomal periostin promotes retinal neovascularization
Exosomes serve as signaling messengers that facilitate intercellular communication through delivering molecular cargo. Here, we observed elevated levels of exosomal periostin (POSTN) in blood plasma of patients with proliferative diabetic retinopathy (PDR). Monocytes-derived exosomal POSTN was incre...
ORGANISM(S): Homo Sapiens 
2025-01-20 | PXD059956 |
GenomicsRNA analysis of the circadian rhythm of choroidal neovascularization
RNA analysis of the circadian rhythm of choroidal neovascularization
PRJNA1067979 | ENA
ProteomicsExploring Corneal Neovascularization: An Integrated Approach Using Transcriptomics and Proteomics in an Alkali Burn Mouse Model
Purpose Corneal neovascularization (CNV) impairs corneal transparency and visual acuity. The study aims to deepen our understanding of the molecules involved in CNV induced by alkali burns, facilitate a better grasp of CNV mechanisms, and uncover potential therapeutic targets. Methods Mice were sele...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD047367 | Pride
Transcriptomics  proteomics  alkali burns  corneal neovascularization  mice  lcp1  csrp2  tgm2  tgfbi 
TranscriptomicsGene Expression Profiling In Murine Retina Neovascularization Models
In order to find out the vital genes during retinal neovascularization (RNV), we set up OIR (oxygen-induced retinopathy; induced with 75%±2% oxygen) and wild-type C57BL/6J murine models. We observed the retinal vascular growth process daily both in OIR and wild-type mice through retinal flat-mount,...
ORGANISM(S): Mus musculus 
2012-12-05 | E-GEOD-38762 | biostudies-arrayexpress
GenomicsA local neuronal clock regulates retinal angiogenesis and neovascularization
A local neuronal clock regulates retinal angiogenesis and neovascularization
PRJNA854612 | ENA
GenomicsCircular Slc17a5 regulated by VLDLR/QKI pathway inhibits ocular neovascularization
Circular Slc17a5 regulated by VLDLR/QKI pathway inhibits ocular neovascularization
PRJNA866118 | ENA
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