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MetabolomicsComparative characterization of the infant gut microbiome and their maternal lineage by a multi-omics approach

The human gut microbiome establishes and matures during infancy, and dysregulation at this stage may lead to pathologies later in life. We conducted a multi-omics study comprising three generations of family members to investigate the early development of the gut microbiota. Fecal samples from 20...

2024-03-07 | MTBLS7670 | MetaboLights
TranscriptomicsThe mosquito Aedes aegypti has a large genome size and high transposable element load but contains a low proportion of transposon-specific piRNAs
Background: The piRNA pathway has been shown in model organisms to be involved in silencing of transposons thereby providing genome stability. In D. melanogaster the majority of piRNAs map to these sequences. The medically important mosquito species Aedes aegypti has a large genome size, a high tran...
ORGANISM(S): Drosophila melanogaster 
2014-03-18 | E-GEOD-33595 | biostudies-arrayexpress
UnknownAdjuvant Therapy of Nivolumab Combined With Ipilimumab Versus Nivolumab Alone in Patients With Resected Stage IIIB-D or Stage IV Melanoma (CheckMate 915).
Not available
S-EPMC9870220 | biostudies-literature
TranscriptomicsTranscriptional profiling of Dicer conditional knockout hematopoietic stem cells.
Gene expression of HSC (Lin-Sca-Kit+Flt3-) hematopoietic stem cells from Dicer D/+ mice was compared with LT-HSC from DicerD/D mice. BM cells were noncompetitively transplanted into irradiant recipients, and deletion induced by poly(IC) injection. Donor-derived HSCs were isolated by FACS sorting ...
ORGANISM(S): Mus musculus 
2012-09-21 | E-MTAB-674 | biostudies-arrayexpress
UnknownGene variant effects across sodium channelopathies predict function and guide precision therapy.
Not available
S-EPMC9897196 | biostudies-literature
TranscriptomicsEffects of antagonist of retinoid X receptor (UVI3003) on morphology and gene profile of Xenopus tropicalis embryos
Retinoid X receptor (RXR) plays an important role in the development of vertebrates, and the agonists of RXR are well-known to induce featured malformations in vertebrate embryos. However, there is no information about the teratogenicity of antagonists of RXR in vertebrate embryos. We exposed embryo...
ORGANISM(S): Xenopus (Silurana) tropicalis 
2014-02-13 | E-GEOD-54929 | biostudies-arrayexpress
UnknownExpanding Clinical Presentations Due to Variations in THOC2 mRNA Nuclear Export Factor.
Not available
S-EPMC7026477 | biostudies-literature
UnknownPancreatic Histopathology of Human Monogenic Diabetes Due to Causal Variants in KCNJ11, HNF1A, GATA6, and LMNA.
Not available
S-EPMC5761488 | biostudies-literature
TranscriptomicsMicroarray analysis of human umbilical vein endothelial cells (HUVECs) chronically irradiated with low dose-rate of ionizing radiation for one, three and six weeks.
To obtain more insight in the molecular effects of chronic low dose irradiation on endothelial cells, HUVEC were irradiated with low-dose rate irradiation (137Cs gamma source; 0, 1.4 and 4.1 mGy/h) for several weeks. At different time points (1, 3 and 6 weeks) cells were harvested for RNA extraction...
ORGANISM(S): Homo sapiens 
2018-02-28 | E-MTAB-6521 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of differences between multipotent stromal cells isolated from human bone marrow, umbilical cord blood and placenta
Unrestricted somatic stem cells (USSCs) from human cord blood show distinct differences to multipotent stromal cells isolated from human bone marrow and placenta both at the gene array and functional level. Fibroblast samples and raw data also included in E-TABM-724.
ORGANISM(S): Homo sapiens 
2014-11-26 | E-TABM-880 | biostudies-arrayexpress
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