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TranscriptomicsAtorvastatin, rosuvastatin and rifampicin effect on human primary hepatocyte transcriptome [Affymetrix platform]
With particular emphasis on interactions between cholesterol homeostasis and drug metabolism we investigate the transcriptome of human primary hepatocytes treated by two commonly prescribed cholesterol lowering drugs atorvastatin and rosuvastatin and by rifampicin that serves as an outgroup as well ...
ORGANISM(S): Homo sapiens 
2011-09-04 | E-GEOD-24187 | biostudies-arrayexpress
TranscriptomicsAtorvastatin, rosuvastatin and rifampicin effect on human primary hepatocyte transcriptome
This SuperSeries is composed of the following subset Series: GSE24186: Atorvastatin, rosuvastatin and rifampicin effect on human primary hepatocyte transcriptome [Steroltalk platform] GSE24187: Atorvastatin, rosuvastatin and rifampicin effect on human primary hepatocyte transcriptome [Affymetrix pla...
ORGANISM(S): Homo sapiens 
2011-09-04 | E-GEOD-24188 | biostudies-arrayexpress
TranscriptomicsAtorvastatin, rosuvastatin and rifampicin effect on human primary hepatocyte transcriptome [Steroltalk platform]
With particular emphasis on interactions between cholesterol homeostasis and drug metabolism we investigate the transcriptome of human primary hepatocytes treated by two commonly prescribed cholesterol lowering drugs atorvastatin and rosuvastatin and by rifampicin that serves as an outgroup as well ...
ORGANISM(S): Homo sapiens 
2011-09-04 | E-GEOD-24186 | biostudies-arrayexpress
TranscriptomicsInhibition of proliferation and induction of autophagy by atorvastatin in PC3 prostate cancer cells correlate with downregulation of Bcl2 and upregulation of miR-182 and p21 [miRNA expression]
The epidemiologic association between statin use and decreased risk of advanced prostate cancer suggests that statins may inhibit prostate cancer development and/or progression. Studies were performed to determine the effects of a model statin, atorvastatin (ATO), on the proliferation and different...
ORGANISM(S): Homo sapiens 
2013-09-30 | E-GEOD-46375 | biostudies-arrayexpress
TranscriptomicsInhibition of proliferation and induction of autophagy by atorvastatin in PC3 prostate cancer cells correlate with downregulation of Bcl2 and upregulation of miR-182 and p21 [Gene expression]
The epidemiologic association between statin use and decreased risk of advanced prostate cancer suggests that statins may inhibit prostate cancer development and/or progression. Studies were performed to determine the effects of a model statin, atorvastatin (ATO), on the proliferation and different...
ORGANISM(S): Homo sapiens 
2013-09-30 | E-GEOD-46374 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of aortic media from L-NAME and atorvastatin treated male rats
One-month-old male Fischer 344 rats with an initial body weight of 150 g were used for this study and were divided into 7 groups: a control group (30 days), 2 groups intoxicated with L-NAME (50 mg/kg per day in the drinking water; Sigma Chemical Co) for 15 and 30 days, 2 groups treated with atorvast...
ORGANISM(S): Rattus norvegicus 
2006-12-31 | E-MEXP-33 | biostudies-arrayexpress
TranscriptomicsGene expression profiles in HepG2 cells exposed to atorvastatin
In the exon array data set, gene level analysis was performed on HepG2 cells exposed to atorvastatin. No genes were found to be statistically significantly differentially expressed upon atorvastatin treatment. 3 control and 3 atorvastatin treated HepG2 samples were analysed. Genes with an FDRM-bM-^I...
ORGANISM(S): Homo sapiens 
2014-04-26 | E-GEOD-57071 | biostudies-arrayexpress
TranscriptomicsmRNA-Seq of Lemna minor exposed to different concentrations of the pharmaceutical atorvastatin against untreated control groups
In this study, Lemna minor was used to investigate ecotoxic modes-of-action (MoA) at the gene expression level. For this purpose, mRNA sequencing was applied to plant RNA extracted from L. minor exposed to the pharmaceutical atorvastatin in a shortened version of the OECD guideline test No. 221 (OEC...
ORGANISM(S): Lemna minor 
2022-07-15 | E-MTAB-11459 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human primary HUVECs and an immortalized HUVEC cell line treated with atorvastatin and/or mevalonate
Rationale: Immortalized cells may exhibit important differences relative to their primary cell counterparts. Microarrays were used compare primary human umbilical vein endothelial cells (HUVECs) and the immortalized HUVEC cell line EA.hy926, in their response to inhibition of the mevalonate pathway ...
ORGANISM(S): Homo sapiens 
2007-08-21 | E-GEOD-2450 | biostudies-arrayexpress
TranscriptomicsAtorvastatin Reduces β-Adrenergic Dysfunction in Rats with Diabetic Cardiomyopathy
Background: In the diabetic heart the β-adrenergic response is altered partly by down-regulation of the β1-adrenoceptor, reducing its positive inotropic effect and up-regulation of the β3-adrenoceptor, increasing its negative inotropic effect. Statins have clinical benefits on morbidity and morta...
ORGANISM(S): Rattus norvegicus 
2017-06-27 | E-MTAB-5594 | biostudies-arrayexpress
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