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MetabolomicsMacrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques
Macrophages represent a major immune cell population in atherosclerotic plaques and play central role in the progression of this lipid-driven chronic inflammatory disease. Targeting immunometabolism is proposed as a strategy to revert aberrant macrophage activation to improve disease outcome. Here, ...
2021-03-05 | MTBLS2159 | MetaboLights
MetabolomicsExtracellular ATP is an environmental cue in bacteria

In animals and plants extracellular ATP (eATP) functions as signal and regulates the immune response. During inflammation intestinal bacteria are exposed to elevated eATP originating from the mucosa. However, whether bacteria respond to eATP is unclear. Here we show that non-pathogenic Escherichi...

2025-08-28 | MTBLS12905 | MetaboLights
MetabolomicsF1Fo-ATP synthase subunit determines lethal pathogenic fungi infection
Fungal infections, especially candidiasis and aspergillosis, claim an unacceptably high fatality rate. The energy ATP that is necessary for fungal cell growth and function is synthesized mainly through oxidative phosphorylation, with the key enzyme being F1Fo-ATP synthase. But it remains unknown how...
2021-10-08 | MTBLS3332 | MetaboLights
MetabolomicsUntargeted metabolites of supernatant of wild-type and Nlrp3-/- bone marrow-derived macrophages with or without LPS and ATP costimulation
Untargeted metabolites of supernatant of wild-type and Nlrp3-/- bone marrow-derived macrophages without stimulation or with 4 hours of LPS preconditioning and subsequently 30 min of ATP stimulation.
2025-07-08 | MTBLS12152 | MetaboLights
MetabolomicsATP-binding Cassette Sub-family C Member 5 (ABCC5) Functions as an Efflux Transporter of Glutamate Conjugates and Analogs
The ubiquitous efflux transporter ATP-binding cassette sub-family C member 5 (ABCC5) is present at high levels in the blood-brain barrier, neurons and glia, but its function is not known. Untargeted metabolomic screens revealed that Abcc5-/- mice accumulate endogenous glutamate conjugates in several...
2015-11-02 | MTBLS197 | MetaboLights
MetabolomicsTargeted polyamine metabolomics of ATP13A4-deficient cellular and mouse models

ATP13A4 is a polyamine transporter enriched in astrocytes that regulates extracellular polyamine homeostasis. This study contains targeted LC-MS/MS metabolomics data from ATP13A4-deficient cellular and mouse models, including C8-D1A astrocytic cells, astrocyte-conditioned medium, mouse cortex, pl...

2026-06-10 | MTBLS14724 | MetaboLights
TranscriptomicsATP effect on Arabidopsis roots
Extracellular adenosine 5’-triphosphate (ATP) is a signaling molecule. To define the global transcriptional response to ATP, we performed DNA microarray analysis using RNA derived from wild-type (Col-0) Arabidopsis and the dorn1-1 mutant, Lectin receptor kinase I.9 (At5g60300) carrying a EMS point m...
ORGANISM(S): Arabidopsis thaliana 
2014-01-27 | E-GEOD-52610 | biostudies-arrayexpress
MetabolomicsMitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance
Not available
ORGANISM(S): Homo sapiens 
ST001730 | MetabolomicsWorkbench
MetabolomicsFunctional metabolic molecules were identified as novel therapeutic targets to facilitate gemcitabine treatment against pancreatic cancer (Cells metabolomics with ATP)
Not available
ORGANISM(S): Homo sapiens 
ST002255 | MetabolomicsWorkbench
MetabolomicsMitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance (part-III)
Not available
ORGANISM(S): Homo sapiens 
ST001732 | MetabolomicsWorkbench
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