Atp-competitive inhibition

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HDX-MS Analysis of Conformation Selection by ATP-competitive Inhibitors and Allosteric Communication in ERK2

Activation of the extracellular signal regulated kinase-2 (ERK2) by phosphorylation has been shown to involve changes in protein dynamics, as determined by hydrogen-deuterium exchange mass spectrometry (HDX-MS) and NMR relaxation dispersion measurements. These can be described by a global exchange b...

ORGANISM(S): Rattus norvegicus (Rat)

2024-03-20 | PXD048311 | Pride

Structural insights into the competitive inhibition of the ATP-gated P2X receptor channel.

Not available

S-EPMC5638823 | biostudies-literature

Genome-wide CRISPR-Cas9 knockout screen in MCF10A with ATP-competitive inhibition of CDC7 (XL-413)

PRJEB123051 | ENA

Neoamphimedine circumvents metnase-enhanced DNA topoisomerase IIα activity through ATP-competitive inhibition.

Not available

S-EPMC3229241 | biostudies-literature

ATP competitive protein kinase C inhibitors demonstrate distinct state-dependent inhibition.

Not available

S-EPMC3197134 | biostudies-literature

Structural and Functional Analysis of the Allosteric Inhibition of IRE1α with ATP-Competitive Ligands.

Not available

S-EPMC4992410 | biostudies-literature

A Non-ATP-Competitive Dual Inhibitor of JAK2 and BCR-ABL Kinases: Elucidation of a Novel Therapeutic Spectrum Based on Substrate Competitive Inhibition.

Not available

S-EPMC2921666 | biostudies-literature

AT13148 is a novel, oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity

Purpose: Deregulated phosphatidylinositol 3-kinase pathway signaling through AGC kinases including AKT, p70S6 kinase, PKA, SGK and Rho kinase, is a key driver of multiple cancers. The simultaneous inhibition of multiple AGC kinases may increase antitumor activity and minimize clinical resistance com...

ORGANISM(S): Homo sapiens

2012-07-19 | E-GEOD-38008 | biostudies-arrayexpress

Discovery of a Potent Dihydrooxadiazole Series of Non-ATP-Competitive MK2 (MAPKAPK2) Inhibitors.

Not available

S-EPMC4025861 | biostudies-literature

Distinct resistance mechanisms arise to allosteric vs. ATP-competitive AKT inhibitors

PRJNA578183 | ENA

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