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TranscriptomicsTranscription profiling of mouse WT Erk1 and Erk2 deficient CD8 T cells
Comparison of unstimulated and in vitro activated wild type and Erk1 or Erk2 deficient CD8 T cells
ORGANISM(S): Mus musculus 
2008-10-07 | E-MEXP-1833 | biostudies-arrayexpress
TranscriptomicsRNA-seq of canine MDCK epithelial cell line compared to cell line overexpressing ERK2 or cell line with conditional activation of the ERK pathway
Using RNA-seq and canine MDCK epithelial cells, we analyzed mRNA expression profiles of cells overexpressing ERK2 and cells where the ERK pathway was activated for 24 hrs. For this purpose, three cell lines were used: parental MDCK cells, MDCK cells overexpressing FLAG-ERK2 or MDCK cells expressing ...
ORGANISM(S): Canis lupus familiaris 
2022-10-01 | E-MTAB-12132 | biostudies-arrayexpress
TranscriptomicsGenomic Collaboration of Estrogen Receptor-α and ERK2 in Regulating Gene and Proliferation Programs
The nuclear hormone receptor, estrogen receptor-alpha (ERα), and MAP kinases both play key roles in hormone-dependent cancers, yet their interplay and the integration of their signaling inputs remain poorly understood. In these studies, we document that estrogen-occupied ERα activates and interact...
ORGANISM(S): Homo sapiens 
2011-01-10 | E-GEOD-24592 | biostudies-arrayexpress
ProteomicsHDX-MS Analysis of Conformation Selection by ATP-competitive Inhibitors and Allosteric Communication in ERK2
Activation of the extracellular signal regulated kinase-2 (ERK2) by phosphorylation has been shown to involve changes in protein dynamics, as determined by hydrogen-deuterium exchange mass spectrometry (HDX-MS) and NMR relaxation dispersion measurements. These can be described by a global exchange b...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-03-20 | PXD048311 | Pride
Atp-competitive inhibition Map kinase Hdx-ms Conformation selection Erk2 
ProteomicsDeamidation and phosphorylation sites on SrfH-treated ERK2 kinase
This project has the aim of identifying possible post-translational modifications induced by the Salmonella effector SrfH on the host kinase ERK2.
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium str. 14028s Wu Homo sapiens (Human) Escherichia coli 
2016-06-20 | PXD003304 | Pride
Deamidation Bacterial effector Post-translational modification Phosphorylation 
TranscriptomicsGene expression profiling of the palate in Erk2 mutant mouse models
The overall goal of this project is to investigate the role of Erk2-mediated signaling in regulating the cellular metabolism of cranial neural crest (CNC) cells during palate development. Here, we conducted gene expression profiling of palate tissue from wild type mice as well as those with a neural...
ORGANISM(S): Mus musculus 
2015-12-11 | E-GEOD-67087 | biostudies-arrayexpress
ProteomicsTAP-ERK2-K52R MS analysis of 1D gel bands
MS analysis of 1D gel bands from TAP-ERK2-K52R immunoprecipitation experiments
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000088047 | MassIVE
GenomicsERK2-dependent gene expression
ERK2-dependent gene expression
PRJNA514405 | ENA
TranscriptomicsTranscriptional profiling by array after knockdown of ERK2 and ELK1 in human embryonic stem cells
The ERK/MAPK signal transduction cascade is one of the key pathways regulating proliferation and differentiation in development and disease. In human embryonic stem cells (hESCs), ERK signaling is required for their self-renewing property. Here we studied the convergence of the ERK signaling cascade...
ORGANISM(S): Homo sapiens 
2013-05-31 | E-MTAB-1583 | biostudies-arrayexpress
GenomicsChIP-Seq for ERK2/MAPK1 and ELK1 in human embryonic stem cells
The ERK/MAPK signal transduction cascade is one of the key pathways regulating proliferation and differentiation in development and disease. In human embryonic stem cells (hESCs), ERK signaling is required for their self-renewing property. Here we studied the convergence of the ERK signaling cascade...
ORGANISM(S): Homo sapiens 
2013-05-31 | E-MTAB-1565 | biostudies-arrayexpress
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