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TranscriptomicsConditional depletion of intellectual disability and Parkinsonism candidate gene ATP6AP2 in fly and mouse induces cognitive impairment and neurodegeneration
ATP6AP2 is an essential accessory component of the vacuolar H+ ATPase (V-ATPase) and has been associated with intellectual disabilities (ID) and Parkinsonism. ATP6AP2 has been implicated in several signaling pathways, but little is known about its role in the nervous system. To decipher its function...
ORGANISM(S): Mus musculus 
2015-09-22 | E-GEOD-67541 | biostudies-arrayexpress
ProteomicsProteomic Analysis of Plasma Membrane Proteins in Atp6ap2 (PRR)-Deficient Osteoblast-Lineage Cells
ATP6AP2 (also known as PRR) is required for osteocyte maturation and cortical bone development. To identify downstream effectors of ATP6AP2, plasma membrane-enriched proteins were isolated from control and Atp6ap2-deficient osteoblast-lineage cells and analyzed by mass spectrometry. Comparative prot...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-22 | PXD079754 | Pride
Atp6ap2  mmp14  osteoblast  osteocyte  cortical bone  proteomics  mass spectrometry  plasma membrane proteins  bone development 
TranscriptomicsConditional depletion of intellectual disability and Parkinsonism candidate gene ATP6AP2 in fly and mouse induces cognitive impairment and neurodegeneration
ATP6AP2 is an essential accessory component of the vacuolar H+ ATPase (V-ATPase) and has been associated with intellectual disabilities (ID) and Parkinsonism. ATP6AP2 has been implicated in several signaling pathways, but little is known about its role in the nervous system. To decipher its function...
ORGANISM(S): Mus musculus 
2015-09-22 | GSE67541 | GEO
GenomicsRNA sequencing of isolated lung endothelial cells from Wildtype (WT) and PRR(Atp6ap2) endothelial cell-specific mutants
RNA sequencing of isolated lung endothelial cells from Wildtype (WT) and PRR(Atp6ap2) endothelial cell-specific mutants
PRJNA743679 | ENA
UnknownAtp6ap2 ablation in adult mice impairs viability through multiple organ deficiencies.
Not available
S-EPMC5575319 | biostudies-literature
UnknownATP6AP2 functions as a V-ATPase assembly factor in the endoplasmic reticulum.
Not available
S-EPMC6249795 | biostudies-literature
UnknownATP6AP2 variant impairs CNS development and neuronal survival to cause fulminant neurodegeneration.
Not available
S-EPMC6486358 | biostudies-literature
UnknownEndothelial cell polarity and extracellular matrix composition require functional ATP6AP2 during developmental and pathological angiogenesis.
Not available
S-EPMC9675464 | biostudies-literature
UnknownA Novel GLP1 Receptor Interacting Protein ATP6ap2 Regulates Insulin Secretion in Pancreatic Beta Cells.
Not available
S-EPMC4599009 | biostudies-literature
UnknownSynonymous variants in the ATP6AP2 gene may lead to developmental and epileptic encephalopathy.
Not available
S-EPMC10808393 | biostudies-literature
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