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TranscriptomicsTranscription profiling of shoot apices from Arabidopsis wild type, teb, atr, and teb atr mutant plants
Global gene expression patterns were compared among wild-type Col-0, teb, atr, teb atr of A. thaliana using shoot apices.
ORGANISM(S): Arabidopsis thaliana 
2008-04-01 | E-MEXP-1329 | biostudies-arrayexpress
ProteomicsATM and ATR- dependent protein phosphorylation induced within 15 minutes after gamma irradiation in Arabidopsis thaliana
Pilotexp_IMAC_TiO2_eluate_ATM_ATR_dep_phos_15min_postIR: Proteins were isolated from 4 different conditions of Arabidopsis thaliana plants: wild type untreated, wild type irradiated, atm/atr mutant untreated, atm/atr mutant irradiated The proteins were tryptically digested and labelled each with one...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2015-01-09 | PXD000033 | Pride
Phosphorylation Arabidopsis  wt vs atm Atr double mutant  itraq 
TranscriptomicsDNA damage responses and Mec1p
Eukaryotic cells respond to DNA damage by arresting the cell cycle and modulating gene expression to ensure efficient DNA repair. The human ATR kinase and its homolog in yeast, MEC1, play central roles in transducing the damage signal. To characterize the role of the Mec1 pathway in modulating the c...
ORGANISM(S): Saccharomyces cerevisiae 
2005-09-24 | E-GEOD-3358 | biostudies-arrayexpress
TranscriptomicsTranscriptional response to zebularine and mitomycin C (MMC) in wild type and ATR deficient Arabidopsis thaliana plants
Zebularine is a non-methylable cytidine analog that is used in epigenetic and cancer research. Its application has been shown to activate several transcriptionally silenced genetic elements; however, extent of this activation and other effects on the transcriptome are unknown. Here, we show that zeb...
ORGANISM(S): Arabidopsis thaliana 
2014-11-18 | E-GEOD-63355 | biostudies-arrayexpress
GenomicsDNA damage repair in barley following double-strand breaks and its dependence on ATR
DNA damage repair in barley following double-strand breaks and its dependence on ATR
PRJNA984259 | ENA
TranscriptomicsBudding yeast ATM/ATR contribute to meiotic double-strand-break (DSB) homeostasis by down-regulating Rec114, an essential component of the DSB-machinery
In most organisms, meiotic recombination begins with programmed DNA double strand break (DSB) formation by Spo11. Here, we present evidence that Tel1/Mec1, the budding yeast ATM/ATR, regulate DSB formation by phosphorylating Rec114, an essential Spo11-accessory protein. Analyses of a non-phosphor...
ORGANISM(S): Saccharomyces cerevisiae 
2013-06-01 | E-GEOD-43384 | biostudies-arrayexpress
TranscriptomicsExpression data from 5 day old Arabidopsis thaliana seedlings
Upon induction of DNA damage Arabidopsis thaliana plants initiate a transcriptional response program governed by signalling cascades which are activated by the ATM and ATR kinases To analyse if the ATM dependent gene GMI1 (At5G24280) is involved in the regulation of the transcriptionl response, we c...
ORGANISM(S): Arabidopsis thaliana 
2011-04-21 | E-GEOD-23892 | biostudies-arrayexpress
TranscriptomicsDNA damage repair in barley following double-strand breaks and its dependence on ATR
Maintaining genome integrity presents a particular challenge for plants due to their sedentary lifestyle, which disables direct avoidance of unfavorable external conditions. Additionally, plants’ metabolic processes generate reactive molecules as by-products of e.g. photosynthesis, creating internal...
ORGANISM(S): Hordeum vulgare 
2023-10-19 | GSE235051 | GEO
TranscriptomicsKEAP1 and STK11/LKB1 alterations enhance vulnerability to ATR inhibition in KRAS mutant NSCLC
KRAS mutations frequently co-occur with alterations in STK11/LKB1 and/or KEAP1, defining an aggressive subset of tumors associated with resistance to immuno- and chemotherapy. While LKB1 loss is associated with vulnerability to DNA-damage response (DDR)-based therapies, the impact of KEAP1 alteratio...
ORGANISM(S): Mus musculus 
2025-06-15 | E-MTAB-15235 | biostudies-arrayexpress
ProteomicsAncestral and divergent roles of the Marchantia polymorpha ATAXIA TELANGIECTASIA AND RAD3-RELATED kinase in maintaining genome integrity and clonal fitness
The eukaryotic ATAXIA TELANGIECTASIA AND RAD3-RELATED (ATR) kinase is essential for ensuring genomic integrity under conditions that cause replication defects. It triggers a transient cell cycle arrest and DNA repair by activating the DNA damage response pathway. While ATR kinases appear to be funct...
ORGANISM(S): Marchantia polymorpha 
2026-07-03 | PXD067609 | Pride
Marchantia Genome integrity Dna damage response Double strand breaks Atr kinase Replication stress 
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