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TranscriptomicsExpression data from Shox2 knockout and wildtype right atria of E11.5 mouse hearts
The heartM-bM-^@M-^Ys rhythm is initiated and regulated by a group of specialized cells in the sinoatrial node (SAN), the primary pacemaker of the heart. Abnormalities in the development of the SAN can result in irregular heart rates (arrhythmias). Although several of the critical genes important fo...
ORGANISM(S): Mus musculus 
2013-06-03 | E-GEOD-39924 | biostudies-arrayexpress
TranscriptomicsAffymetrix array of postnatal day 4 mouse atria exposed to room air or hyperoxia
It is unclear why preterm birth increases risk of cardiovascular disease later in life. Studies in mice indicate excess oxygen typically used to treat preterm infants causes pulmonary hypertension, cardiac failure, and shortens lifespan. We previously reported neonatal hyperoxia causes pulmonary hyp...
ORGANISM(S): Mus musculus 
2021-02-23 | E-MTAB-9008 | biostudies-arrayexpress
TranscriptomicsAtrial fibrillation is associated with altered left-to-right atria gene expression ratio: implications for arrhythmogenesis and thrombogenesis
Background: Atrial fibrillation (AF) causes atrial remodeling, and the left atrium (LA) is the favored substrate for maintaining AF. However, it remains unclear if AF remodels both atria differently and contributes to LA arrhythmogenesis and thrombogenesis. Results: AF was associated with differenti...
ORGANISM(S): Homo sapiens 
2016-08-09 | E-GEOD-79768 | biostudies-arrayexpress
TranscriptomicsValvular heart disease and atrial fibrillation regulate microRNA expression profiles in left and right atria differently
Background: Chronic atrial fibrillation (AF) is a complication associated with the dilated atria of patients with valvular heart disease and contributes to worsened pathology. Methods and Results: Using microarray technology, we examined microRNA (miR) expression profiles in right and left atrial ap...
ORGANISM(S): Homo sapiens 
2011-12-21 | E-GEOD-28954 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of normal atria and ventricles
Pharmacological and gene ablation studies have demonstrated a crucial role of the cardiac natriuretic peptides (NP) hormones ANF and BNP in the maintenance of cardiovascular homeostasis. In addition, hypertension and chronic congestive heart failure are clinical entities that may be regarded as st...
ORGANISM(S): Rattus norvegicus 
2009-09-15 | E-GEOD-5266 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of atrial left-right differences in two different mouse strains
Two wild-type mouse strains (Swiss Agouti and MF1) were investigated regarding the mRNA expression patterns of their left and right atria at 12 months of age. Eight samples of each strain, four with left atrium and four with right atrium examined.
ORGANISM(S): Mus musculus 
2011-12-31 | E-GEOD-29500 | biostudies-arrayexpress
TranscriptomicsSex-dependent gene regulatory networks of the heart rhythm
Expression level, control and intercoordination of 66 selected heart rhythm determinant (HRD) genes were compared in atria and ventricles of 4 male and 4 female adult mice. We found that genes encoding various adrenergic receptors, ankyrins, ion channels and transporters, connexins and other compone...
ORGANISM(S): Mus musculus 
2009-08-12 | E-GEOD-17324 | biostudies-arrayexpress
TranscriptomicsTranscriptome of Nkx2-5-null atria
Atrial specific knockout of Nkx2-5 results in hyperplastic atria with ASD and conduction defects. To examine how Nkx2-5 regulates cardiac proliferation at late gestational stages, RNA-seq was performed. Examination of expression profile of 2 Nkx2-5-null atria and 3 controls
ORGANISM(S): Mus musculus 
2014-10-31 | E-GEOD-52080 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human atrial and ventricular myocardium from patients atrial tissue of patients with sinus rhythm vs. human left ventricular non-failing myocardium to identify the transcriptional basis for ultrastructural and functional specialization of human atria and ventricles
Note this data set has identical data files: Files GSM40994.txt and GSM40995.txt. GSE2240 contains two different experimental subsets:; 1) Comparison of atrial and ventricular gene expression (atrial tissue of patients with sinus rhythm vs. human left ventricular non-failing myocardium); The purpose...
ORGANISM(S): Homo sapiens 
2007-10-27 | E-GEOD-2240 | biostudies-arrayexpress
TranscriptomicsLeft-right transcriptomic differences in adult male mouse heart atria
Left and right heart atria of adult male mice were profiled to determine the differences in gene expression, control, coordination and signaling fabrics Two-sides (L= left, R = right) gene expression profiling experiment in adult mouse male (M) atria (A). 4 biological replicates: MAL1-4, MAR1-4. Thi...
ORGANISM(S): Mus musculus 
2013-03-20 | E-GEOD-45339 | biostudies-arrayexpress
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