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MetabolomicsNon-targeted LC–MS metabolomics of human left atrial appendage tissue with high vs low myocardial micro(nano)plastic burden

Non-targeted metabolomics profiling was performed on human left atrial appendage tissue obtained from cardiac surgery patients. Samples were grouped by myocardial nanoplastic (NP) burden (High vs Low). Polar metabolites were analyzed by UHPLC–Orbitrap MS in both positive and negative ionization m...

2026-03-28 | MTBLS14056 | MetaboLights
TranscriptomicsRac1-Induced Connective Tissue Growth Factor regulates Connexin 43 and N-Cadherin Expression in Atrial Fibrillation
Objectives: We studied the signal transduction of atrial structural remodelling that contributes to the pathogenesis of atrial fibrillation (AF). Backround: Fibrosis is a hallmark of arrhythmogenic structural remodelling but the underlying molecular mechanisms are incompletely understood. Methods: W...
ORGANISM(S): Homo sapiens 
2010-02-21 | E-GEOD-14975 | biostudies-arrayexpress
ProteomicsMultiomic analysis of PI3K in Atrial Myopathy
Here, we undertook comprehensive physiological and molecular analyses in cardiac-specific transgenic mice with increased or decreased PI3K to assess the dose response impact of directly regulating PI3K. Elevated PI3K was associated with a dose-dependent increase in heart size, and preserved/enhanced...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000092855 | MassIVE
GenomicsAtrial myocytes-derived exosomal microRNA contributes to atrial fibrosis in atrial fibrillation
Atrial myocytes-derived exosomal microRNA contributes to atrial fibrosis in atrial fibrillation
PRJNA868203 | ENA
GenomicsSelective blockade of microRNA-31-5p/calcitonin receptor interaction reverses established atrial fibrosis and atrial arrhythmia burden
Selective blockade of microRNA-31-5p/calcitonin receptor interaction reverses established atrial fibrosis and atrial arrhythmia burden
PRJNA1249040 | ENA
TranscriptomicsAtrial myocytes-derived exosomal microRNA contributes to atrial fibrosis in atrial fibrillation
Background Atrial fibrosis plays a critical role in the development of atrial fibrillation (AF). Exosome is a promising cell-free therapeutic approach for the treatment of AF. The purpose of this study was to explore the mechanisms underlying exosomes derived from atrial myocytes regulated atrial re...
ORGANISM(S): Rattus norvegicus 
2022-08-17 | GSE210894 | GEO
ProteomicsHeart proteomics of pathological atrial enlargement associated with atrial fibrillation
Atrial fibrillation (AF) remains challenging to prevent and treat. It is associated with increased rates of heart failure, stroke and neurological decline. A key feature of AF is atrial enlargement. However, not all atrial enlargement progresses to pathology and AF. In the current study, we charact...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-12-07 | MSV000093605 | MassIVE
ProteomicsTime-series proteome profiling analysis of the atria in a murine model of angiotensin II-induced atrial fibrillation
Atrial fibrillation (AF) is the most common form of arrhythmia observed in clinical cardiac diseases. Angiotensin II (Ang II) and elevation of blood pressure have been considered to be the main risk regulators of AF. However, the time series proteome profiling and the key signaling pathways involved...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-04 | PXD022238 | Pride
Proteomics  time series protein expression profiling  angiotensin ii  atrial fibrillation 
GenomicsEndothelial plasticity in atrial fibrosis by integrating single-cell sequencing and genetic lineage tracing
Endothelial plasticity in atrial fibrosis by integrating single-cell sequencing and genetic lineage tracing
PRJNA814215 | ENA
TranscriptomicsSelective blockade of microRNA-31-5p/calcitonin receptor interaction reverses established atrial fibrosis and atrial arrhythmia burden
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is promoted by atrial fibrosis, a form of structural remodelling for which effective therapies are lacking. MicroRNA-31-5p (miR-31-5p), an ageing-associated, atrial-enriched microRNA, has been linked to AF, but its role in ...
ORGANISM(S): Homo sapiens 
2026-09-11 | GSE294333 | GEO
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