Sort   by:  
 Page size 
TranscriptomicsTranscriptome analysis of WT and ATRX KO Cast x 129 mouse ES cells
Analysis of gene expression in WT and ATRX KO Cast x 129 Mouse ES cells Paired end RNA-seq analysis of PolyA selected RNA and PolyA depeleted RNA from in both wildtype nd ATRX knocked out Castx129 Mouse ES Cells
ORGANISM(S): Mus musculus 
2015-04-16 | E-GEOD-59269 | biostudies-arrayexpress
GenomicsGenome-wide ChIP seq of H3.3 in WT and ATRX KO mouse ES cells
Regions of H3.3 binding in WT and ATRX KO mouse ES cells were identified by ChIP seq Chip-seq experiements were performed in WT and ATRX KO E14 mouse ES cells
ORGANISM(S): Mus musculus 
2015-04-16 | E-GEOD-59270 | biostudies-arrayexpress
GenomicsATRX tolerates activity-dependent histone H3 M-bM-^@M-^\methyl/phos switchingM-bM-^@M-^] to maintain repetitive element silencing in neurons
ATRX is a member of the SWI2/SNF2 family of chromatin remodeling proteins and primarily functions at heterochromatic loci via its recognition of M-bM-^@M-^XrepressiveM-bM-^@M-^Y histone modifications (e.g., H3K9me3). Despite significant roles for ATRX during normal neural development, as well as its...
ORGANISM(S): Mus musculus 
2015-01-02 | E-GEOD-64062 | biostudies-arrayexpress
GenomicsATRX-mediated chromatin association of histone variant macroH2A1 regulates alpha globin gene expression
The histone variant macroH2A generally associates with transcriptionally inert chromatin, however the factors that regulate its chromatin incorporation remain elusive. Here, we identify the SWI/SNF helicase, ATRX, as a novel macroH2A interacting protein. Unlike its role in assisting H3.3 chromatin d...
ORGANISM(S): Homo sapiens 
2012-03-08 | E-GEOD-35339 | biostudies-arrayexpress
TranscriptomicsGene expression profile of peripheral blood mononuclear cells in the X-linked alpha thalassemia mental retardation (ATRX) syndrome
ATRX is a severe X-linked disorder characterized by mental retardation, facial dysmorphism, urogenital abnormalities and alpha-thalassemia. The disease is caused by mutations in ATRX gene, which encodes a protein belonging to the SWI/SNF DNA helicase family, a group of proteins involved in the regul...
ORGANISM(S): Homo sapiens 
2010-12-31 | E-GEOD-22028 | biostudies-arrayexpress
ProteomicsMapping RNA interactions of human ATRX with RepA fragment of Xist
Heterochromatin in the eukaryotic genome is rigorously controlled by the concerted action of protein factors and RNAs. Here, we investigate the RNA binding function of ATRX, a chromatin remodeler with roles in silencing of repetitive regions of the genome and in recruitment of the polycomb repressi...
ORGANISM(S): Homo sapiens (Human) 
2020-03-09 | PXD017806 | Pride
Rbrid  rna-protein interactions  rna-binding 
GenomicsA SNF2 protein targets variable copy number repeats and thereby influences allele-specific expression
ATRX is an X-linked gene of the SWI/SNF family whose role in vivo is currently unknown. Mutations in ATRX cause syndromal mental retardation. ATRX binds to tandem repeat (TR) sequences both in heterochromatin (e.g. telomeres) and euchromatin. Genes associated with these TRs can be dysregulated when ...
ORGANISM(S): Homo sapiens 
2010-11-02 | E-GEOD-22162 | biostudies-arrayexpress
GenomicsThe chromatin remodeler ATRX binds to atypical chromatin domains at the 3’ exons of ZNF genes to preserve H3K9me3 enrichment
Here, we report that ATRX co-localizes with the H3K9-methyl transferase SETDB1 (also known as ESET), the co-repressor TRIM28 (also known as KAP1), and the transcription factor ZNF274 at 3’ exons of Zinc Finger Genes (ZNFs) containing an atypical H3K9me3/H3K36me3 chromatin signature. Disruption of ...
ORGANISM(S): Homo sapiens 
2016-04-05 | E-GEOD-70920 | biostudies-arrayexpress
GenomicsWT and ATRX KO
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-04-16 | E-GEOD-59271 | biostudies-arrayexpress
TranscriptomicsThe SWI/SNF protein ATRX co-regulates pseudoautosomal genes that have translocated to autosomes in the mouse genome
Pseudoautosomal regions (PAR1 and PAR2) in eutherians retain homologous regions between the X and Y chromosomes that play a critical role in the obligatory X-Y crossover during male meiosis. Genes that reside in the PAR1 are exceptional in that they are rich in repetitive sequences and undergo a ve...
ORGANISM(S): Mus musculus 
2009-08-01 | E-GEOD-12454 | biostudies-arrayexpress
Sort   by:  
 Page size