Sort   by:  
 Page size 
MetabolomicsRepair-Associated Macrophages Increase after Early-phase Microglia Attenuation to Promote Ischemic Stroke Recovery

Ischemic stroke recovery involves dynamic interactions between the central nervous system and infiltrating immune cells. Peripheral immune cells compete with resident microglia for spatial niches in the brain, but how modulating this balance affects recovery remains unclear. Here, we use PLX5622 ...

2025-02-20 | MTBLS12240 | MetaboLights
Metabolomics12,13-diHOME protects against the age-related decline in cardiovascular function via attenuation of CaMKII.

Liquid chromatography mass spectrometry (LC-MS/MS) on plasma of young (aged 24-40) and aged (aged 65-90) human subjects. 

2025-06-26 | MTBLS12646 | MetaboLights
MetabolomicsSchisandra chinensis alleviates dextran sulfate sodium-induced colitis in association with remodeling of a Parabacteroides goldsteinii-related leucine– isovalerate metabolic axis and attenuation of mTOR/HIF-1α/IL-17 signaling

Ulcerative colitis (UC) involves epithelial injury, gut microbial dysbiosis, disturbed microbial metabolism, and mucosal inflammation. This study evaluated the protective effect of Schisandra chinensis (SC) against dextran sulfate sodium (DSS)-induced UC and investigated the underlying microbiota...

2026-08-29 | MTBLS15496 | MetaboLights
MetabolomicsGPR109a-AMPK Axis Mediates the Attenuation of Uric Acid-Induced M1 Macrophage Polarization by β-hydroxybutyrate from Lacticaseibacillus rhamnosus M2b

Hyperuricemia (HUA) is a metabolic disorder marked by increased blood uric acid (UA) levels, closely linked to conditions such as gout. UA-induced macrophage M1 polarization fundamentally exacerbates inflammatory pathophysiology, but current HUA-specific immunoregulatory treatments are inadequat...

2026-01-26 | MTBLS13224 | MetaboLights
GenomicsCombinitorial Approaches to Viral Attenuation
Combinitorial Approaches to Viral Attenuation
PRJNA474818 | ENA
ProteomicsTranslocational attenuation regulated by PERK-SRP14 axis is a novel protective mechanism of UPR
Translocational attenuation regulated by PERK-SRP14 axis is a novel protective mechanism of UPR
ORGANISM(S): Homo Sapiens 
PXD052453 |
TranscriptomicsHost responses contributing to the attenuation of severe acute respiratory syndrome coronaviruses missing E protein domains
Severe acute respiratory syndrome coronavirus (SARS-CoV) causes a respiratory disease leading to death in 10% of the infected people. A mouse adapted SARS-CoV lacking the envelope (E) protein (rSARS-CoV-MA15-?E) is attenuated in vivo. To identify E protein domains and host responses that contribute ...
ORGANISM(S): Mus musculus 
2015-05-19 | E-GEOD-59185 | biostudies-arrayexpress
ProteomicsAttenuation of ATM signaling by ROS delays replicative senescence at physiological oxygen
Replicative senescence, a powerful tumor suppressor pathway, occurs when a few critically-short telomeres activate the DNA damage response (DDR). We show that ATM is the sole DDR kinase responsible for the induction and maintenance of replicative senescence and that ATM inhibition can induce normal ...
ORGANISM(S): Homo sapiens (Human) 
2026-02-12 | PXD069897 | Pride
GenomicsA Variant allele in Varicella-Zoster Virus Glycoprotein B, Selected during Production of the Varicella Vaccine, Contributes to its Attenuation
On the basis of vOka attenuation
PRJEB53195 | ENA
TranscriptomicsCombinitorial Approaches to Viral Attenuation
Attenuated viruses have numerous applications, in particular in the context of live viral vaccines. However, purposefully designing attenuated viruses remains challenging, in particular if the attenuation is meant to be resistant to rapid evolutionary recovery. Here we develop and analyze a new atte...
ORGANISM(S): Escherichia phage T7 
2018-06-07 | GSE115396 | GEO
Sort   by:  
 Page size