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GenomicsCombinitorial Approaches to Viral Attenuation
Combinitorial Approaches to Viral Attenuation
PRJNA474818 | ENA
ProteomicsTranslocational attenuation regulated by PERK-SRP14 axis is a novel protective mechanism of UPR
Translocational attenuation regulated by PERK-SRP14 axis is a novel protective mechanism of UPR
ORGANISM(S): Homo Sapiens 
PXD052453 |
TranscriptomicsHost responses contributing to the attenuation of severe acute respiratory syndrome coronaviruses missing E protein domains
Severe acute respiratory syndrome coronavirus (SARS-CoV) causes a respiratory disease leading to death in 10% of the infected people. A mouse adapted SARS-CoV lacking the envelope (E) protein (rSARS-CoV-MA15-?E) is attenuated in vivo. To identify E protein domains and host responses that contribute ...
ORGANISM(S): Mus musculus 
2015-05-19 | E-GEOD-59185 | biostudies-arrayexpress
ProteomicsAttenuation of ATM signaling by ROS delays replicative senescence at physiological oxygen
Replicative senescence, a powerful tumor suppressor pathway, occurs when a few critically-short telomeres activate the DNA damage response (DDR). We show that ATM is the sole DDR kinase responsible for the induction and maintenance of replicative senescence and that ATM inhibition can induce normal ...
ORGANISM(S): Homo sapiens (Human) 
2026-02-12 | PXD069897 | Pride
GenomicsA Variant allele in Varicella-Zoster Virus Glycoprotein B, Selected during Production of the Varicella Vaccine, Contributes to its Attenuation
On the basis of vOka attenuation
PRJEB53195 | ENA
TranscriptomicsCombinitorial Approaches to Viral Attenuation
Attenuated viruses have numerous applications, in particular in the context of live viral vaccines. However, purposefully designing attenuated viruses remains challenging, in particular if the attenuation is meant to be resistant to rapid evolutionary recovery. Here we develop and analyze a new atte...
ORGANISM(S): Escherichia phage T7 
2018-06-07 | GSE115396 | GEO
TranscriptomicsAffect of antiviral ribavirin on YFV WT and vaccine strains.
Live-attenuated viral vaccines have been successfully used to combat infectious disease for decades but due to their empirical derivation, little is known about their mechanisms of attenuation. This lack of understanding makes the development of next generation live attenuated vaccines difficult. Th...
ORGANISM(S): Yellow fever virus 
2020-01-01 | E-MTAB-8504 | biostudies-arrayexpress
GenomicsAttenuation of the M gene in Vesicular Stomatitis Virus Vector
Attenuation of the M gene in Vesicular Stomatitis Virus Vector
PRJNA1259969 | ENA
GenomicsThe molecular basis for the attenuation of the yellow fever 17D vaccine [wtYFV_RNAseq]
The molecular basis for the attenuation of the yellow fever 17D vaccine [wtYFV_RNAseq]
PRJNA1151155 | ENA
GenomicsThe molecular basis for the attenuation of the yellow fever 17D vaccine [chimerasYFVs_RNAseq]
The molecular basis for the attenuation of the yellow fever 17D vaccine [chimerasYFVs_RNAseq]
PRJNA1151208 | ENA
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