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TranscriptomicsGene expression data from ATRT tumor samples
Atypical teratoid/rhabdoid tumor (ATRT) is one of the most common brain tumors in infants. Although the prognosis of ATRT patients is poor, some patients respond favorably to current treatments, suggesting molecular inter-tumor heterogeneity. To investigate this further, we genetically and epigeneti...
ORGANISM(S): Homo sapiens 
2016-03-02 | E-GEOD-70678 | biostudies-arrayexpress
TranscriptomicsHigh expression of BMP pathway genes distinguishes a subset of Atypical Teratoid/Rhabdoid Tumors associated with shorter survival
Molecular profiling of tumors has proven a valuable tool for identification of prognostic and diagnostic subgroups in medulloblastomas, glioblastomas and other cancers. However, the molecular landscape of atypical teratoid / rhabdoid tumors (AT/RTs) remains largely unexplored. To address this issue,...
ORGANISM(S): Homo sapiens 
2011-09-21 | E-GEOD-28026 | biostudies-arrayexpress
ProteomicsNatural and cryptic peptides dominate the immunopeptidome of atypical teratoid rhabdoid tumors.
Atypical teratoid/rhabdoid tumors (AT/RT) are highly aggressive CNS-tumors of infancy and early childhood. Hallmark is the surprisingly simple genomics with a truncating mutation in the SMARCB1 gene as the oncogenic driver. Nevertheless, AT/RTs are infiltrated by immune cells and even clonally expan...
ORGANISM(S): Homo sapiens (Human) 
2022-05-31 | PXD033935 | Pride
Human Primary at/rt tumors Hla-i and hla-ii 
ProteomicsPrimary cilia contribute to the aggressiveness of atypical teratoid/rhabdoid tumors
Atypical teratoid/rhabdoid tumor (AT/RT) is the most common malignant brain tumor in infants and is characterized by loss of nuclear SMARCB1 protein expression. Recent studies show that AT/RTs comprise three molecular subgroups with epigenetic differences, including distinct expression patterns of g...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD027211 | Pride
Atypical teratoid/rhabdoid tumor Targeted therapy Stat1/dr5 signaling Primary cilia 
TranscriptomicsHistone deacetylase inhibition decreases proliferation and potentiates the effect of ionizing radiation in atypical teratoid/rhabdoid tumor cells
Atypical teratoid/rhabdoid tumor (ATRT) is a highly malignant CNS neoplasm whichprimarily occurs in children under three years of age. Due to poor outcomes with intense and toxicmultimodality treatment, new therapies are urgently needed. Histone deacetylase inhibitors (HDIs)have been evaluated as no...
ORGANISM(S): Homo sapiens 
2011-11-14 | E-GEOD-31122 | biostudies-arrayexpress
GenomicsRNA sequencing data from primary atypical teratoid rhabdoid tumor (ATRT) samples
RNA sequencing data from primary atypical teratoid rhabdoid tumor (ATRT) samples
PRJNA674345 | ENA
TranscriptomicscaArray_golub-00460: Prediction of central nervous system embryonal tumour outcome based on gene expression
Embryonal tumours of the central nervous system (CNS) represent a heterogeneous group of tumours about which little is known biologically, and whose diagnosis, on the basis of morphologic appearance alone, is controversial. Medulloblastomas, for example, are the most common malignant brain tumour of...
ORGANISM(S): Homo sapiens 
2015-05-16 | E-GEOD-68956 | biostudies-arrayexpress
UnknownA Systematic Review of Atypical Teratoid Rhabdoid Tumor in Adults.
Not available
S-EPMC6279935 | biostudies-literature
UnknownCase-based review: atypical teratoid/rhabdoid tumor.
Not available
S-EPMC6656328 | biostudies-literature
UnknownRecent progress and novel approaches to treating atypical teratoid rhabdoid tumor.
Not available
S-EPMC9929860 | biostudies-literature
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