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TranscriptomicsTranscriptional Profiling of the Megabladder Mouse - A Unique Model of Bladder Dysmorphogenesis
Recent studies in our lab have identified a mutant mouse model of obstructive nephropathy designated mgb for megabladder. Homozygotic mgb mice (mgb-/-) develop lower urinary tract obstruction in utero due to a lack of bladder smooth muscle differentiation. This defect is the result of a random trans...
ORGANISM(S): Mus musculus 
2007-08-09 | E-GEOD-8715 | biostudies-arrayexpress
TranscriptomicsWaves of early transcriptional activation and pluripotency program initiation along human preimplantation development.
The events regulating human preimplantation development are still largely unknown, due to scarcity of material, ethical and legal limitations, and lack of reliable techniques to faithfully amplify the transcriptome of a single cell. Nonetheless, knowledge in human embryology is gathering renewed int...
ORGANISM(S): Homo sapiens 
2011-07-18 | E-GEOD-29397 | biostudies-arrayexpress
TranscriptomicsThe UBC-40 Urothelial Bladder Cancer Cell Line Index [copy number variation]
This is a comprehensive genomic characterization of 40 urothelial bladder carcinoma (UBC) cell lines including information on origin, mutation status of genes implicated in bladder cancer (FGFR3, PIK3CA, TP53, and RAS), copy number alterations assessed using high density SNP arrays, uniparental diso...
ORGANISM(S): Homo sapiens 
2015-06-19 | E-GEOD-64572 | biostudies-arrayexpress
TranscriptomicsThe UBC-40 Urothelial Bladder Cancer Cell Line Index [gene expression]
This is a comprehensive genomic characterization of 40 urothelial bladder carcinoma (UBC) cell lines including information on origin, mutation status of genes implicated in bladder cancer (FGFR3, PIK3CA, TP53, and RAS), copy number alterations assessed using high density SNP arrays, uniparental diso...
ORGANISM(S): Homo sapiens 
2015-06-19 | E-GEOD-64279 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse HOXB4 in adult hematopoietic stem and progenitor cells with inducible HOXB4 to identify its target genes
HOXB4 mediates expansion of adult and embryo-derived hematopoietic stem cells (HSCs) when expressed ectopically. To define the underlying molecular mechanisms, we performed gene expression profiling in combination with subsequent functional analysis using enriched adult HSCs expressing inducible HO...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9010 | biostudies-arrayexpress
Genomicsena-DATASET-MUG-17-05-2013-08:29:19:239-74 - samples
We performed serial plasma-Seq analyses on a male who progressed from castration-sensitive to castration-resistant prostate cancer within 10 months following treatment with androgen-deprivation therapy.
EGAD00001000396 | EGA
Genomicsena-DATASET-MUG-19-03-2013-14:10:31:964-87 - samples
We performed low coverage whole genome sequencing of plasma DNA from prostate cancer patients to establish copy number profiles on both a genome-wide and a gene-specific level. The data include plasma samples from prostate cacner patients (n=13), non-malignant controls (males, n=10 and females, n=9)...
EGAD00001000364 | EGA
Genomicsena-DATASET-MUG-19-03-2013-14:14:47:994-92 - samples
In this study we analysed patients with metastatic prostate cancer to scan their tumor genomes noninvasively in plasma DNA. We enriched 1.3 Mbp of seven plasma DNAs (4 CRPC cases: CRPC1-3 and CRPC5; 3 CSPC cases: CSPC1-2 and CSPC4) including exonic sequences of 55 cancer genes and 38 introns of 18 g...
EGAD00001000365 | EGA
GenomicsPlasma-Seq of patients with metastatic prostate cancer
Study 1 In this study we analysed patients with metastatic prostate cancer to scan their tumor genomes noninvasively in plasma DNA. We wanted to make whole-genome analysis from plasma DNA amenable to clinical routine applications and developed an approach based on a benchtop high-throughput platform...
EGAS00001000451 | EGA
GenomicsIdentification of mutations and structural rearrangements in plasma DNA form metastatic prostate cancer patients
In this study we analysed patients with metastatic prostate cancer to scan their tumor genomes noninvasively in plasma DNA. We enriched 1.3 Mbp of seven plasma DNAs (4 CRPC cases: CRPC1-3 and CRPC5; 3 CSPC cases: CSPC1-2 and CSPC4) including exonic sequences of 55 cancer genes and 38 introns of 18 g...
EGAS00001000453 | EGA
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