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ProteomicsTemporal multi-omics identifies LRG1 as vascular instructor of early metastatic colonization.
Metastasis is the primary cause of cancer-related mortality and the mechanistically least well understood step of the tumor progression cascade. Employing surgical preclinical metastasis models, we show here that small primary tumors reprogram the body’s vascular endothelium to alter systemic homeos...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-16 | PXD013978 | Pride
And vascular niche Lrg1 Endothelial cells Cancer Metastasis 
TranscriptomicsWhole genome profiling of whole liver lysates of vehicle and Sorafenib-treated iAST mice
Analysis of changes in gene expression upon Sorafenib treatment. Looking for candidates, that could potentially be up- or down-regulated upon Sorefanib treatment. Total RNA were optained from whole liver lysates of vehicle 14d-, Sorafenib 14d- and LT Sorafenib-treated iAST mice
ORGANISM(S): Mus musculus 
2014-06-20 | E-GEOD-54857 | biostudies-arrayexpress
ProteomicsA vascular phosphoproteome atlas unveils a functional Tie‑Wnt signalling axis in the liver
Single cell transcriptomic analyses (scRNAseq) of hepatocytes and liver endothelial cells (L-EC) have revolutionized the understanding of the spatial architecture of liver structure and function. The spatial alignment of L-EC and hepatocytes is pivotal for liver function in health and disease given ...
ORGANISM(S): Mus musculus (Mouse) 
2021-05-21 | PXD020805 | Pride
Wnt Vasculature Liver Phospho-proteome Endothelial Zonation Tie 
ProteomicsA vascular phosphoproteome atlas unveils a functional Tie‑Wnt signalling axis in the liver
Single cell transcriptomic analyses (scRNAseq) of hepatocytes and liver endothelial cells (L-EC) have revolutionized the understanding of the spatial architecture of liver structure and function. The spatial alignment of L-EC and hepatocytes is pivotal for liver function in health and disease given ...
ORGANISM(S): Mus musculus (Mouse) 
2021-05-20 | PXD020760 | Pride
Multi-omics Vasculature Liver Endothelial Phospho proteome Spatial sorting Zonation 
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