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ProteomicsLRG1 is an adipokine that promotes insulin sensitivity and suppresses inflammation
While dysregulation of adipocyte endocrine function plays a central role in obesity and its complications, the vast majority of adipokines remain uncharacterized. We employed bio-orthogonal non-canonical amino acid tagging (BONCAT) and mass spectrometry to comprehensively characterize the secretome ...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-21 | PXD035318 | Pride
Lrg1 Adipokine Inflammation Insulin 
GenomicsAAV-mediated LRG1 overexpression in diabetic mice
AAV-mediated LRG1 overexpression in diabetic mice
PRJNA858802 | ENA
ProteomicsTemporal multi-omics identifies LRG1 as vascular instructor of early metastatic colonization.
Metastasis is the primary cause of cancer-related mortality and the mechanistically least well understood step of the tumor progression cascade. Employing surgical preclinical metastasis models, we show here that small primary tumors reprogram the body’s vascular endothelium to alter systemic homeos...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-16 | PXD013978 | Pride
And vascular niche Lrg1 Endothelial cells Cancer Metastasis 
GenomicsRNA sequencing of keratinocytes with or without LRG1 addition
RNA sequencing of keratinocytes with or without LRG1 addition
PRJNA505485 | ENA
Proteomicsserum exosomes contain SPARC and LRG1 as biomarkers for colon cancer and differ by tumor primary location
Purpose: Over the past few years, the distinction between left- and right-sided colon cancer has been brought into focus. Right-sided tumor location was associated with an inferior overall survival and progression-free survival. We aimed to perform a detailed analysis of the diversity in exosomes be...
ORGANISM(S): Homo sapiens (Human) 
2019-11-25 | PXD012283 | Pride
Exosome Proteomics Colon cancer Lrg1 Sparc Location Metastasis 
UnknownCrystal structure of LRG1 and the functional significance of LRG1 glycan for LPHN2 activation.
Not available
S-EPMC10238393 | biostudies-literature
GenomicsPhospho-antibody microarray anayses for control and DG-LRG1 treated HUVEC cells.
Phospho-antibody microarray anayses for control and DG-LRG1 treated HUVEC cells.
PRJNA671594 | ENA
TranscriptomicsAAV-mediated LRG1 overexpression in diabetic mice
To investigate the effect of LRG1 overexpression on gene expression of eWAT from db/db mice, we transduced 4-week-old db/db mice with AAV8-eGFP or AAV8-LRG1-FL and harvested eWAT at 7 weeks and 10 weeks of age. We then performed gene expression profiling analysis using data obtained from RNA-seq of ...
ORGANISM(S): Mus musculus 
2022-07-18 | GSE208219 | GEO
GenomicsLRG1 loss effectively restrains glomerular TGF-β signaling to attenuate DKD in diabetic mice
LRG1 loss effectively restrains glomerular TGF-β signaling to attenuate DKD in diabetic mice
PRJNA1122216 | ENA
GenomicsLRG1 is an adipokine that mediates obesity-induced hepatosteatosis and insulin resistance [heaptocyte_RNA-seq]
LRG1 is an adipokine that mediates obesity-induced hepatosteatosis and insulin resistance [heaptocyte_RNA-seq]
PRJNA769182 | ENA
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