Sparc - OmicsDI

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Homo sapiens (63)
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Technology Type

Mass Spectrometry (41)
MEMA (24)
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Affinity purification coupled with mass spectrometry proteomics (3)
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-- (1)
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2016 (40)
2025 (23)
2020 (18)
2026 (17)
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2013 (9)
2010 (8)
2008 (7)
2017 (6)
2014 (6)
2012 (6)
2011 (4)
2018 (4)
2006 (3)
2007 (3)
2004 (2)
2015 (2)
2005 (1)

CHEBI ID

CHEBI:20506 (1)
CHEBI:37736 (1)
CHEBI:22651 (1)
CHEBI:139582 (1)
CHEBI:51340 (1)
CHEBI:15633 (1)
CHEBI:17925 (1)
CHEBI:15811 (1)
CHEBI:17482 (1)
CHEBI:16765 (1)
CHEBI:16160 (1)
CHEBI:15467 (1)
CHEBI:44409 (1)
CHEBI:15350 (1)
CHEBI:18053 (1)
CHEBI:17202 (1)
CHEBI:16344 (1)
CHEBI:16856 (1)
CHEBI:15978 (1)
CHEBI:15346 (1)
CHEBI:18406 (1)
CHEBI:17981 (1)
CHEBI:42334 (1)
CHEBI:52742 (1)
CHEBI:16708 (1)
CHEBI:27470 (1)
CHEBI:16750 (1)
CHEBI:16977 (1)
CHEBI:25017 (1)
CHEBI:15428 (1)

Metabolite Name

5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate (1)
Pristanic acid (1)
Acetyl phosphate (1)
N-acetyl-DL-methionine (1)
N-acetyl-D-tryptophan (1)
D-ribose 5-phosphate (1)
1-aminocyclopropane-1-carboxylate (1)
Alpha-D-glucose (1)
O-phospho-L-serine (1)
Glutarate (1)
5-oxo-L-proline (1)
L-cystathionine (1)
Alpha-ketoglutaric acid (1)
O-acetyl-L-carnitine (1)
Tryptamine (1)
5-hydroxy-L-tryptophan (1)
Sphinganine (1)
Hippurate (1)
Benzoate (1)
Pyridoxal (1)
O-succinyl-L-homoserine (1)
Glutathione (1)
L-carnitine (1)
Uridine (1)
Urate (1)
Taurine (1)
Guanosine (1)
Guanidinoacetate (1)
Carnosine (1)
Xanthine (1)

First Public Date

2014 (22)
2023 (15)
2025 (14)
2024 (14)
2022 (13)
2026 (12)
2021 (10)
2020 (10)
2019 (8)
2017 (6)
2016 (4)
2018 (3)
2013 (2)
2015 (1)

Classification

protozoa (2)
bacteria (1)

Study status

Recruiting (1)

Study type

Transcription profiling by array (38)
RNA-seq of coding RNA (8)
Unknown experiment type (3)
RNA-seq of coding RNA from single cells (3)
Transcription profiling by SAGE (1)
High-throughput sequencing (1)
Cell line - High-throughput sequencing (1)
Transcription profiling by RT-PCR (1)
Methylation profiling by array (1)
Observational patient registry (1)

Release Date

2025 (103)
2023 (100)
2022 (92)
2024 (82)
2021 (79)
2020 (69)
2019 (50)
2018 (40)
2015 (39)
2016 (35)
2017 (30)
2013 (29)
2014 (27)
2011 (23)
2009 (22)
2010 (20)
2008 (20)
2012 (19)
2026 (13)
2007 (11)
2005 (4)
2004 (4)
2006 (3)
2003 (2)
2002 (1)
2001 (1)

Lab affiliation

National Key Laboratory of Medical Molecular Biology & Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (2)
University of Vienna, Faculty of Chemistry, Department of Analytical Chemistry (2)
Department of Neurology, University of Miami, Miller School of Medicine (1)
Professor, Department of Molecular Genetics, University of Toronto, Canada Scientific Director, SPARC BioCentre, Hospital for Sick Children (Sickkids), Toronto, Canada (1)
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 (1)
Koç University Rumelifeneri Yolu 34450 Istanbul Turkey (1)
Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, College of Life Sciences,Shaanxi Normal University,Xi'an,Shaanxi,China (1)
Montpellier Cancer Research Institute lab : Protease, Microenvironment and Cancer (1)
Neurosurgeon & Senior Scientist Developmental and Stem Cell Biology, The Hospital for Sick Children, Canada (1)
Division of Endocrinology, Diabetes, and Clinical Nutrition, University Hospital Zurich, Switzerland (1)
Department of Laboratory Medicine and Pathobiology, University of Toronto (1)
Laboratory for Applied Science and Technology in Health, Carlos Chagas Institute, Oswaldo Cruz Foundation (Fiocruz), Curitiba, Brazil (1)
Sunnybrook Research Institute, Toronto, ON, Canada / Department of Biochemistry, University of Toronto, Toronto, ON, Canada / Department of Biochemistry and Molecular Biology, Alberta Children’s Hospital Research Institute, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada / Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada (1)
Department of Plasma Proteins, Sanquin-AMC Landsteiner Laboratory, Amsterdam, The Netherlands (1)
SPARC Biocentre, The Hospital for Sick Children, Program in Cell Biology, The Hospital for Sick Children, Department of Medical Biophysics, University of Toronto. (1)
Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada, M5S 1A8 (1)
Department of Biochemistry, Albert Einstein College of Medicine, The Bronx, NY 10461, United States (1)
Department of Biology, York University, Toronto, ON M3J 1P3, Canada (1)
The University of Guelph, Guelph, Ontario, Canada. The department of Biomedical Sciences at the Ontario Veterinary College. (1)
Centre for Proteomic Research, University of Southampton (1)
Professor, Department of Biochemistry and Molecular Biology, University of Miami, Miller School of Medecine (1)
Department of Physiology, School of Biomedical Sciences, Faculty of Medicine Dentistry and Health Sciences, The University of Melbourne, Victoria 3010 Australia (1)
National Heart and Lung Institute, Imperial College London, London, SW7 2AZ, UK (1)
Professor Director, Executive Ph.D. Program Department of Biochemistry & Molecular Biology Sylvester Comprehensive Cancer Center Miller School of Medicine University of Miami Gauthier Build, room 216 Laboratory, rooms 215, 218, 225 Miami, FL 33101-6129 Tel: (305) 243-5177 cell: (305) 877-9731 (1)
Program in Cell Biology Hospital For Sick Children, Toronto, SPARC BioCentre Hospital For Sick Children, Toronto, 8Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada (1)
Hansen He lab, Princess Margaret Cancer Center, University Health Network, Canada. (1)
The Department of Biomedicine University of Bergen, Norway (1)
York University (1)
Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Experimental Hematology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China. (1)
University Medical Center Göttingen, Institute of Clinical Chemistry, Core Facility Proteomics (1)

Location

Canada (1)

Keyword

Advanced endoscopy (1)
Colorectal neoplasia (1)
Endoscopic resection (1)

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Genome-wide analysis of SPARC(secreted protein acidic and rich in cysteine)-responsive gene expression in HTR-8/SVneo cells

SPARC is a matricellular glycoprotein that plays critical roles in the pathologies associated with obesity and diabetes, as well as tumorigenesis. The objective of this study was to investigate the role of SPARC in the process of trophoblast invasion which shares many similarities with tumor cells ...

ORGANISM(S): Homo sapiens

2012-04-27 | E-GEOD-37639 | biostudies-arrayexpress

4T1 breast tumors: SPARC knock down primary tumors vs. Control primary tumors vs. Lung metastasis foci

Comparative analysis of the transcriptome of primary tumors generated from 4T1 cells transduced with a lentiviral vector expressing a siRNA against murine SPARC (4T1-C18), primary tumors generated from 4T1 cells transduced with a lentiviral vector expressing a scramble sequence (4T1-SCR) or lung met...

ORGANISM(S): Mus musculus

2016-06-29 | E-GEOD-83831 | biostudies-arrayexpress

Role of SPARC in autoimmunity

PRJNA603581 | ENA

4T1 breast cancer cells: SPARC knock down vs. Control

Comparative analysis of the transcriptome of 4T1 cells stably transduced with a lentiviral vector expressing a siRNA against murine SPARC (4T1-C18) with 4T1 control cells stably transduced with a lentiviral vector expressing a scramble sequence (4T1-SCR). Two-condition experiment, 4T1-C18 vs. 4T1-SC...

ORGANISM(S): Mus musculus

2016-06-29 | E-GEOD-83830 | biostudies-arrayexpress

Transcription profiling of mouse SPARC-null vs. wild-type lens epithelium

SPARC is a matricellular glycoprotein involved in regulation of the extracellular matrix, growth factors, adhesion, and migration. SPARC-null mice have altered basement membranes and develop posterior sub-capsular cataracts with cell swelling and equatorial vacuoles. Exchange of fluid, nutrients, ...

ORGANISM(S): Mus musculus

2009-05-11 | E-GEOD-13402 | biostudies-arrayexpress

EP3 deletion in macrophages aggravates diet-induced obesity in mice by suppressing SPARC

Macrophages are primary immune cells involved in obesity-triggered chronic low-grade inflammation in adipose tissues. Prostaglandin (PG) E2, mainly generated from macrophages, can regulate adipose tissue remodeling. Here, we observed that PGE2 receptor subtype 3 (EP3) was remarkably downregulated in...

ORGANISM(S): Mus musculus (Mouse)

2025-05-25 | PXD063443 | Pride

SPARC knock down

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

2016-06-29 | E-GEOD-83832 | biostudies-arrayexpress

The SPARC complex defines RNAPII promoters in Trypanosoma brucei

Kinetoplastids are a highly divergent lineage of eukaryotes with unusual mechanisms for regulating gene expression. We previously surveyed 65 putative chromatin factors in the kinetoplastid Trypanosoma brucei. Our analyses revealed that the predicted histone methyltransferase SET27 and the Chromodom...

ORGANISM(S): Trypanosoma brucei

2023-03-11 | PXD036454 | Pride

Set27 promoter-associated regulatory complex (sparc) Chromodomain protein crd1 Trypanosoma brucei Histone methyltransferase set27

serum exosomes contain SPARC and LRG1 as biomarkers for colon cancer and differ by tumor primary location

Purpose: Over the past few years, the distinction between left- and right-sided colon cancer has been brought into focus. Right-sided tumor location was associated with an inferior overall survival and progression-free survival. We aimed to perform a detailed analysis of the diversity in exosomes be...

ORGANISM(S): Homo sapiens (Human)

2019-11-25 | PXD012283 | Pride

Exosome Proteomics Colon cancer Lrg1 Sparc Location Metastasis

Effect of SPARC on gene expression in HepG2

PRJNA704276 | ENA

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