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TranscriptomicsIdentification of genes are regulated by AURKA at transcription level
Purpose: AURKA plays an important role in breast cancer development. Exploring the gene expression profiles regulated by AURKA will facilitate to understand the mechanism which is responsible for AURKA induced breast cancer development. Results: We found that 350 genes were significantly up-regulat...
ORGANISM(S): Homo sapiens 
2015-10-28 | E-GEOD-57931 | biostudies-arrayexpress
TranscriptomicsRNAi knock down of AURKA in human neuroblastoma IMR-32 cells
IMR-32 cells were infected either with control-shRNA or one of two different AURKA-shRNA vectors to identify genes regulated after AURKA knockdown.
ORGANISM(S): Homo sapiens 
2008-06-01 | E-MEXP-1496 | biostudies-arrayexpress
ProteomicsTargeted AURKA degradation: Towards new therapeutic agents for neuroblastoma
Aurora kinase A (AURKA) is a well-established target in neuroblastoma (NB) due to both its catalytic functions during mitosis and its kinase-independent functions, including stabilization of the key oncoprotein MYCN. We present a structure-activity relationship (SAR) study of MK-5108-derived PROTACs...
ORGANISM(S): Homo sapiens (Human) 
2023-02-27 | PXD040389 | Pride
Aurka  mycn  neuroblastoma  protac  targeted protein degradation 
ProteomicsTargeted AURKA degradation: Towards new therapeutic agents for neuroblastoma
Aurora kinase A (AURKA) is a well-established target in neuroblastoma (NB) due to both its catalytic functions during mitosis and its kinase-independent functions, including stabilization of the key oncoprotein MYCN. We present a structure-activity relationship (SAR) study of MK-5108-derived PROTACs...
ORGANISM(S): Homo sapiens (Human) 
2023-02-27 | PXD040391 | Pride
Aurka  mycn  neuroblastoma  protac  targeted protein degradation 
GenomicsIdentification of genes are regulated by AURKA at transcription level
Identification of genes are regulated by AURKA at transcription level
PRJNA527723 | ENA
GenomicsAURKA-Mediated 7-Dehydrocholesterol Biosynthesis Drives Ferroptosis Evasion and Chemoresistance
AURKA-Mediated 7-Dehydrocholesterol Biosynthesis Drives Ferroptosis Evasion and Chemoresistance
PRJNA1291086 | ENA
GenomicsHuman CRC cells (Caco2 and SW480): AURKA siRNA vs non targeted siRNA
Human CRC cells (Caco2 and SW480): AURKA siRNA vs non targeted siRNA
PRJNA431623 | ENA
ModelsAurora Kinase A in Neuroblastoma
Aurora Kinase A (AURKA) is often overexpressed in neuroblastoma (NB) with poor outcome. The causes of AURKA overexpression in NB are unknown. Here, we describe a gene regulatory network consisting of core regulators of AURKA protein expression and activation during mitosis to identify potential caus...
7916 | Cell Collective
TranscriptomicsExpression profiling tumor cells from MYCN-driven neuroblastoma upon BRD4 or AURKA inhibition
Amplification of MYCN is the most prominent genetic marker of high-stage neuroblastoma, a childhood tumor originating from the neural crest. We generated a cell line (mNB-A1) from tumors developed in transgenic mouse and treated these cells with DMSO (n=6), the BRD4-inhibitor JQ1 (n=3) or the AURKA-...
ORGANISM(S): Mus musculus 
2014-09-01 | E-GEOD-57810 | biostudies-arrayexpress
TranscriptomicsIdentification of genes are regulated by AURKA at transcription level
Purpose: AURKA plays an important role in breast cancer development. Exploring the gene expression profiles regulated by AURKA will facilitate to understand the mechanism which is responsible for AURKA induced breast cancer development. Results: We found that 350 genes were significantly up-regulate...
ORGANISM(S): Homo sapiens 
2015-10-28 | GSE57931 | GEO
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