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ProteomicsProximity-based activation of AURORA A by MPS1 potentiates error correction
Faithfull cell division relies on mitotic chromosomes becoming bioriented with each pair of sister kinetochores bound to microtubules from opposing spindle poles. Erroneous kinetochore- microtubule attachments often form during early mitosis, but are destabilized through the phosphorylation of outer...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2025-04-03 | PXD056173 | Pride
Auroraa In vitro phosphorylation assay Mitosis 
UnknownMultiple Functions of the Essential Gene PpV in Drosophila Early Development.
Not available
S-EPMC6829155 | biostudies-literature
UnknownMitotic HOOK3 phosphorylation by ERK1c drives microtubule-dependent Golgi destabilization and fragmentation.
Not available
S-EPMC8215223 | biostudies-literature
ProteomicsIdentification of Pimavanserin tartrate as a Potent Ca2+-Calcineurin-NFAT Pathway Inhibitor for Glioblastoma Therapy
Glioblastoma multiforme (GBM) is the most common and most malignant primary brain tumor. Although alkylating agents (such as temozolomide (TMZ)) are widely used as first-line treatments for GBM, they often cause chemoresistance and are poorly effective for recurrent GBM. Therefore, anti-GBM drugs wi...
ORGANISM(S): Homo Sapiens 
2020-12-17 | PXD023207 |
UnknownCharacterization of pancreatic glucagon-producing tumors and pituitary gland tumors in transgenic mice overexpressing MYCN in hGFAP-positive cells.
Not available
S-EPMC5342675 | biostudies-literature
TranscriptomicsThe novel atypical retinoid ST5589 down-regulates Aurora Kinase A and has anti-tumour activity in lymphoma pre-clinical models
we report characterized the preclinical activity of a new member of this class, the ST1926-derivative ST5589, in lymphomas GEP analysis of 2 lymphoma cell lines with and without treatment
ORGANISM(S): Homo sapiens 
2016-01-08 | E-GEOD-66455 | biostudies-arrayexpress
TranscriptomicsThe investigational Aurora kinase A inhibitor MLN8237 induces defects in cell viability and cell cycle progression in mouse bladder cancer cells in vitro and in vivo
PURPOSE: Despite over 70,000 new cases of bladder cancer in the United States annually, patients with advanced disease have a poor prognosis due to limited treatment modalities. We evaluate the role of Aurora A, identified as an upregulated candidate molecule in bladder cancer, in regulating bladde...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-42089 | biostudies-arrayexpress
UnknownIdentification of pimavanserin tartrate as a potent Ca2+-calcineurin-NFAT pathway inhibitor for glioblastoma therapy.
Not available
S-EPMC8563877 | biostudies-literature
ModelsAurora Kinase A in Neuroblastoma
Aurora Kinase A (AURKA) is often overexpressed in neuroblastoma (NB) with poor outcome. The causes of AURKA overexpression in NB are unknown. Here, we describe a gene regulatory network consisting of core regulators of AURKA protein expression and activation during mitosis to identify potential caus...
7916 | Cell Collective
Genomics
Repurposing Pimavanserin tartrate as a potent Ca2+-Calcineurin-NFAT Pathway inhibitor for Glioblastoma therapy
PRJNA689001 | ENA
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