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TranscriptomicsTranscription profiling of livers from female C57BL/6J and B6.C3H-6T mice to study differential gene expression in the two strains.
Several studies have shown that bone mineral density (BMD), a clinically measurable predictor of osteoporotic fracture, is the sum of genetic and environmental influences. In addition, serum IGF-1 levels have been correlated to both BMD and fracture risk. We previously identified a Quantitative Tr...
ORGANISM(S): Mus musculus 
2007-11-13 | E-GEOD-5959 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of rat ventricular myocytes cultured with recombinant human interleukin 6
Ventricular myocytes were isolated from adult male Sprague-Dawley rats (250-350g) by collagenase digestion. Cells were cultured with recombinant human interleukin 6 for six hours prior to isolation total RNA by RNeasy mini kit (Qiagen). RNA was amplified and labelled using the Illumina TotalPrep R...
ORGANISM(S): Rattus norvegicus 
2011-07-11 | E-MTAB-344 | biostudies-arrayexpress
TranscriptomicsAddition of IL-6 inhibition to standard GVHD prophylaxis to prevent GVHD after allogeneic stem cell transplantation
BACKGROUND - IL-6 mediates graft-versus-host disease (GVHD) in experimental allogeneic stem cell transplantation (alloSCT) and is an attractive therapeutic target. METHODS - A registered phase I/II study (ACTRN12612000726853) of IL-6 receptor (IL-6R) neutralizing antibody administration on day -1 to...
ORGANISM(S): Homo sapiens 
2014-09-09 | E-GEOD-61201 | biostudies-arrayexpress
TranscriptomicsGenomics-based molecular epidemiology of human clinical and feedlot cattle C. jejuni isolates in Alberta, Canada
Oligonucleotide DNA microarrays were used as a platform to compare C. jejuni isolates from feedlot cattle and human clinical cases from Alberta. Comparative genomic hybridization (CGH) analysis was performed on 87 isolates (46 bovine, 41 human) obtained within the same geographical regions and time ...
ORGANISM(S): Campylobacter jejuni 
2010-05-18 | E-GEOD-13228 | biostudies-arrayexpress
TranscriptomicsA genetically engineered ovarian cancer mouse model based on fallopian tube transformation mimics human high-grade serous carcinoma development
Recent evidence suggests that ovarian high-grade serous carcinoma (HGSC) originates from the epithelium of the fallopian tube. However, most mouse models are based on the previous prevailing view that ovarian cancer develops from the transformation of the ovarian surface epithelium. Here, we report ...
ORGANISM(S): Mus musculus 
2014-04-11 | E-GEOD-52011 | biostudies-arrayexpress
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