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TranscriptomicsKLF1, KLF2 and c-myc control a regulatory network essential for embryonic erythropoiesis
The Krüppel-like factors, KLF1 and KLF2, positively regulate embryonic β-globin expression, and have additional overlapping roles in embryonic (primitive) erythropoiesis. KLF1-/-KLF2-/- double knockout mice are anemic at embryonic day 10.5 (E10.5) and die by E11.5, in contrast to single knockouts. T...
ORGANISM(S): Mus musculus 
2012-03-12 | E-GEOD-36427 | biostudies-arrayexpress
TranscriptomicsGene expression in primary human macrophages and foam cells
The aim of the experiment was to determine the effects of 48 hours of treatment with oxidized low density lipoprotein (oxLDL) on gene expression in primary human monocyte-derived macrophages. 6 independent biological replicates were processed. From each replicate half of the cells were treated with ...
ORGANISM(S): Homo sapiens 
2015-04-08 | E-GEOD-54666 | biostudies-arrayexpress
UnknownMolecular profiling and targeted therapy for advanced thoracic malignancies: a biomarker-derived, multiarm, multihistology phase II basket trial.
Not available
S-EPMC4356709 | biostudies-literature
TranscriptomicsTranscription profiling of rat model of hypertension kidney reveals gender-selective responses to salt in Dahl-Iwai and Sprague-Dawley strains
Dahl-Iwai (DI) salt-sensitive rats were studied using microarrays to identify gender-specific differences in the kidney, both basal differences and responses to a high salt diet. In DI rat kidneys, gene expression profiles demonstrated inflammatory and fibrotic responses selectively in females. Gona...
ORGANISM(S): Rattus norvegicus 
2008-06-13 | E-GEOD-5285 | biostudies-arrayexpress
TranscriptomicsTMPRSS2 Influences Prostate Cancer Metastasis
TMPRSS2 is an androgen-regulated cell surface serine protease expressed predominantly in prostate epithelium. TMPRSS2 is expressed highly in localized high-grade prostate cancers and in the majority of human prostate cancer metastasis. Through the generation of mouse models with a targeted deletion ...
ORGANISM(S): Mus musculus 
2014-09-09 | E-GEOD-58822 | biostudies-arrayexpress
ProteomicsGadd45a Promotes Skeletal Muscle Atrophy by Forming a Complex with the Protein Kinase MEKK4
Skeletal muscle atrophy is a serious and highly prevalent condition that remains poorly understood at the molecular level. Previous work found that skeletal muscle atrophy involves an increase in skeletal muscle Gadd45a expression, which is necessary and sufficient for skeletal muscle fiber atrophy...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2016-05-17 | MSV000079730 | MassIVE
TranscriptomicsStromal-Based Signatures for the Classification of Gastric Cancer [PRT1]
Increasing success is being achieved in the treatment of malignancies with stromal-targeted therapies, predominantly in anti-angiogenesis and immunotherapy, predominantly checkpoint inhibitors. Despite 15 years of clinical trials with anti-VEGF pathway inhibitors for cancer, we still find ourselves ...
ORGANISM(S): Mus musculus 
2016-01-07 | E-GEOD-76588 | biostudies-arrayexpress
TranscriptomicsZbtb16 Has a Role in Brown Adipocyte Bioenergetics
Study designed to identify genes that are induced in both BAT and skeletal muscle during acute adaptive thermogenesis in mouse using gene expression microarray. Animal studies were performed under approved UCLA animal research protocols and according to guidelines established in the Guide for Care ...
ORGANISM(S): Mus musculus 
2012-08-31 | E-GEOD-40486 | biostudies-arrayexpress
TranscriptomicsmiRNAs in ovarian cancer: A systems approach (miRNA data)
MicroRNAs (miRNAs) are short (~22 nucleotides) regulatory RNAs that can modulate gene expression and are aberrantly expressed in many diseases including cancer. We report the results of a systems analysis of miRNA regulation in ovarian cancer. We found that 33 miRNAs are up-regulated and 9 down-regu...
ORGANISM(S): Homo sapiens 
2011-07-28 | E-GEOD-23383 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Cftr knockout or wild type colonic epithelial cells treated with rosiglitazone
30-day-old Cftr-/- homozygous for the S489X, B6.129P2-Cftr(tm1Unc), mutation or sibling wild-type control mice were treated with standard chow or 20 mg/kg/d rosiglitazone for 5 days. Colonic epithelial cells were extracted and mRNA isolated. Cftr-/- mice suffer from a severe intestinal phenotype inc...
ORGANISM(S): Mus musculus 
2010-03-19 | E-MTAB-188 | biostudies-arrayexpress
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