Autoinhibition - OmicsDI

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Philipps-Universität Marburg Zentrum für Synthetische Mikrobiologie (SYNMIKRO) Karl-von-Frisch-Straße 14 35043 Marburg (1)
Department of Structural and Computational Biology, Max Perutz Labs, Campus Vienna Biocenter 5, 1030 Vienna, Austria (1)
Biological NMR and HDX-MS Platform, Institut Pasteur, Université Paris Cité, CNRS UMR 3528, 75015 Paris, France (1)
Department of Structural and Computational Biology, Max Perutz Labs, Campus Vienna Biocenter 5, 1030 Vienna, Austria Department of Medical Biochemistry, Medical University of Vienna, 1090 Vienna, Austria (1)
School of Biochemistry, Biomedical Sciences Building, University Walk, University of Bristol, BS8 1TD, U.K. (1)
Biomedicine Discovery Institute, Monash University, Clayton 3800, Victoria, Australia (1)

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Structural basis of MICAL autoinhibition

MICAL proteins play a crucial role in cellular dynamics by binding and disassembling actin filaments, impacting processes like axon guidance, cytokinesis, and cell morphology. Their cellular activity is tightly controlled, as dysregulation can lead to detrimental effects on cellular morphology. Alth...

ORGANISM(S): Homo sapiens (Human)

2024-10-30 | PXD057312 | Pride

A structural model for the autoinhibition of the γ-TuRC-activating CM1 domain

Microtubule nucleation by γ-tubulin ring complexes (γ-TuRCs) must be spatiotemporally controlled to avoid major cell division errors. γ-TuRCs are activated by the centrosome-specific binding of a highly conserved Centrosomin Motif 1 (CM1) domain, but how binding is prevented in the cytosol remains u...

ORGANISM(S): Drosophila melanogaster (Fruit fly)

2026-10-01 | PXD077066 | Pride

Saxs Cm1 domain Autoinhibition Γ-turcs Hdx-ms Nmr

PTPN21 and Hook3 relieve KIF1C autoinhibition and activate intracellular transport

The kinesin-3 KIF1C is a fast organelle transporter implicated in the transport of dense core vesicles in neurons and the delivery of integrins to cell adhesions. Here we report the mechanisms of autoinhibition and release that control the activity of KIF1C. We show that the microtubule binding surf...

ORGANISM(S): Homo sapiens (Human)

2019-06-24 | PXD013939 | Pride

Autoinhibition Ptpn21 Hook3 Kif1c

RAF conformational autoinhibition and 14-3-3 proteins promote paradoxical activation

PRJNA745935 | ENA

Multiple domain interfaces mediate SARM1 autoinhibition.

Not available

S-EPMC7848697 | biostudies-literature

Talin autoinhibition is required for morphogenesis.

Not available

S-EPMC3882074 | biostudies-literature

DCLK1 autoinhibition and activation in tumorigenesis.