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TranscriptomicsTranscriptional regulation by Pho23 modulates the frequency of autophagosome formation.
Autophagy as a conserved degradation and recycling machinery is important in normal development and physiology, and defects in this process are linked to many kinds of disease. Because too much or too little autophagy can be detrimental, the process must be tightly regulated both temporally and in m...
ORGANISM(S): Saccharomyces cerevisiae 
2014-04-24 | E-GEOD-57031 | biostudies-arrayexpress
GenomicsExamination of hepatic SREBP-2 binding using ChIP-Seq
Sterol regulatory element binding proteins (SREBPs) are key transcriptional regulators of lipid metabolism. To define functional differences between the three mammalian SREBPs we are using genome-wide ChIP-seq with isoform-specific antibodies and chromatin from select tissues of mice challenged with...
ORGANISM(S): Mus musculus 
2011-03-22 | E-GEOD-28082 | biostudies-arrayexpress
GenomicsA lysosomal delivery mechanism required for autophagosome degradation
A lysosomal delivery mechanism required for autophagosome degradation
PRJEB62651 | ENA
ProteomicsMultilayered Regulation of Autophagy by the Atg1 Kinase Orchestrates Spatial and Temporal Control of Autophagosome Formation
Autophagy is a conserved intracellular degradation pathway exerting various cytoprotective and homeostatic functions by utilizing de novo double membrane vesicle (autophagosome) formation to target a wide range of cytoplasmic material for vacuolar/lysosomal degradation. The Atg1 kinase is one of its...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-10-11 | PXD029047 | Pride
Metabolism Protein phosphatases Protein kinases Signalling Phosphorylation Ubiquitin-like proteins Autophagy Atg8 lipidation 
ProteomicsA conserved membrane curvature-generating protein is crucial for autophagosome formation in fission yeast
Organelles are shaped by curvature-generating proteins, which include the reticulons and REEPs that are involved in forming the endoplasmic reticulum (ER). A conserved REEP subfamily differs from the ER-shaping REEPs in abundance and membrane topology and has unidentified functions. Here, we show th...
ORGANISM(S): Schizosaccharomyces pombe 927 
2023-08-06 | PXD043260 | Pride
Reep1 Autophagy Fission yeast 
ProteomicsQuantitative proteomics profilling of p62 droplet
Phase separated p62 body plays pivotal roles during autophagosome formation, however, the underlying mechanisms are still not fully understood. Mass spectrometry-based proteomics revealed significant enrichment of vesicle trafficking components within p62 bodies.
ORGANISM(S): Homo Sapiens Rattus Norvegicus 
2023-06-09 | PXD038262 |
GenomicsmTOR hyperactivation in Down Syndrome mediates deficits in autophagy induction, autophagosome formation, and mitophagy
mTOR hyperactivation in Down Syndrome mediates deficits in autophagy induction, autophagosome formation, and mitophagy
PRJNA523635 | ENA
UnknownAtg41/Icy2 regulates autophagosome formation.
Not available
S-EPMC4835205 | biostudies-literature
UnknownVac8 spatially confines autophagosome formation at the vacuole in S. cerevisiae.
Not available
S-EPMC6899017 | biostudies-literature
UnknownRegulators of autophagosome formation in Drosophila muscles.
Not available
S-EPMC4334200 | biostudies-literature
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