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UnknownATG5 cancer mutations and alternative mRNA splicing reveal a conjugation switch that regulates ATG12-ATG5-ATG16L1 complex assembly and autophagy.
Not available
S-EPMC6796855 | biostudies-literature
UnknownMechanism of cargo-directed Atg8 conjugation during selective autophagy.
Not available
S-EPMC5148612 | biostudies-literature
UnknownThe ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14.
Not available
S-EPMC4835982 | biostudies-literature
UnknownVaccinia virus leads to ATG12–ATG3 conjugation and deficiency in autophagosome formation.
Not available
S-EPMC3327614 | biostudies-literature
ProteomicsTBC1D2B undergoes phase separation and mediates autophagy initiation
Small ubiquitin-like modifiers from the ATG8 family regulate autophagy initiation and progression in mammalian cells. Their interaction with LC3-interacting region (LIR) containing proteins promotes cargo sequestration, phagophore assembly, or even fusion between autophagosomes and lysosomes. Previo...
ORGANISM(S): Homo sapiens (Human) 
2023-09-28 | PXD039959 | Pride
Tbc1d2b Autophagy Phagophore formation Atg8-related proteins Liquid-liquid phase separation Gtpase-activating protein Autophagy conjugation complex 
ProteomicsUnique position of ATG5 in the atg8ylation cascade provides a switch between autophagy and secretion
ATG5 is a part of the E3 ligase directing lipidation of ATG8 proteins (mATG8s), a process central to membrane atg8ylation and its downstream homeostatic manifestations, including canonical autophagy, with impact on health. Genetic ablation of ATG5 in myeloid cells causes mortality in murine models o...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000090348 | MassIVE
UnknownThe parasitophorous vacuole membrane of Toxoplasma gondii is targeted for disruption by ubiquitin-like conjugation systems of autophagy.
Not available
S-EPMC4107903 | biostudies-literature
UnknownATG5 provides host protection acting as a switch in the atg8ylation cascade between autophagy and secretion.
Not available
S-EPMC10205698 | biostudies-literature
UnknownPEBP1, a RAF kinase inhibitory protein, negatively regulates starvation-induced autophagy by direct interaction with LC3.
Not available
S-EPMC5103343 | biostudies-literature
UnknownFunctional Characterisation of the Autophagy ATG12~5/16 Complex in Dictyostelium discoideum.
Not available
S-EPMC7290328 | biostudies-literature
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