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MetabolomicsCPT2 inhibition activates selective autophagy by enhancing glycerophospholipid biosynthesis in colorectal cancer

Metabolic reprogramming is one of the hallmark events in colorectal cancer (CRC).  Tumor cells adapt to microenvironmental changes by regulating energy and biomaterial metabolism. This study identified abnormal lipid accumulation and significant downregulation of fatty acid metabolism in CRC...

2025-09-01 | MTBLS12783 | MetaboLights
TranscriptomicsTranscription profiling of human DU-145, PC-3MM2 cell lines treated with irradiation reveals Mre11 inhibition by oncolytic adenovirus associates with autophagy and underlies synergy with ionizing radiation
Mre11 inhibition by oncolytic adenovirus associates with autophagy and underlies synergy with ionizing radiation
ORGANISM(S): Homo sapiens 
2009-05-13 | E-MEXP-2172 | biostudies-arrayexpress
MetabolomicsThe Inhibition of B7H3 by 2-HG Accumulation Is Associated With Downregulation of VEGFA in IDH Mutated Gliomas
B7H3 (also known as CD276) is a co-stimulator checkpoint protein of the cell surface B7 superfamily. Recently, the function beyond immune regulation of B7H3 has been widely studied. However, the expression preference and the regulation mechanism underlying B7H3 in different subtypes of gliomas is ra...
2021-05-26 | MTBLS2692 | MetaboLights
TranscriptomicsMito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice
Somatic mitochondrial DNA (mtDNA) mutations contribute to the pathogenesis of age-related disorders, including myelodysplastic syndromes (MDS). The accumulation of mitochondria harboring mtDNA mutations in patients with these disorders suggests a failure of normal mitochondrial quality-control syste...
ORGANISM(S): Mus musculus 
2015-04-21 | E-GEOD-57761 | biostudies-arrayexpress
TranscriptomicsLet-7 coordinately suppresses components of the amino acid sensing pathway to induce autophagy
Macroautophagy (hereafter autophagy) is the major pathway by which macromolecules and organelles are degraded. Autophagy is regulated by the mTOR signaling pathway, which is the focal point for integration of metabolic information, with mTORC1 playing a central role in balancing biosynthesis and cat...
ORGANISM(S): Mus musculus 
2015-08-03 | E-GEOD-60452 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of autophagy proficient and compromised cell lines, determined by expression levels of Atg5
Autophagy is activated in pancreatic ductal adenocarcinoma (PDAC) and is currently being considered a promising therapeutic target in clinical trials. PDAC is a highly lethal disease with incidence rate equalling mortality rate. Main reasons for PDAC lethality are late-stage diagnosis, high agressiv...
ORGANISM(S): Mus musculus 
2018-10-15 | E-MTAB-6275 | biostudies-arrayexpress
TranscriptomicsActivation of autophagy by starvation and mTOR inhibition in three human cell lines
The aim of the project was to characterize changes in gene expression that are associated with induced autophagic flux. We engineered HeLa, HEK 293 and SH-SY5Y cell lines to express tandem-fluorecent LC3 (tf-LC3). The ratio of the red and green fluorophores indicated how much of the LC3 is in the ac...
ORGANISM(S): Homo sapiens 
2022-08-25 | E-MTAB-12020 | biostudies-arrayexpress
TranscriptomicsRescue Of Dysfunctional Autophagy By Peptide IDR-1018 Attenuates Hyperinflammatory Phenotype Of Cystic Fibrosis Cells (RNA-seq)
Genome-wide gene expression was measured in peripheral blood mononuclear cells (PBMCs) from patients with cystic fibrosis (CF) after treatment in vitro with the flagellin protein fliC, and/or synthetic peptide IDR-1018 to assess patterns of gene expression. The patterns of gene expression suggest th...
ORGANISM(S): Homo sapiens 
2012-11-20 | E-GEOD-35394 | biostudies-arrayexpress
MetabolomicsIntegrated physiological responses of Macrobrachium rosenbergii to NaHCO3 stress: growth inhibition, energy metabolism activation, oxidative injury, and autophagic response
Saline-alkaline stress, particularly sodium bicarbonate-induced alkaline stress, can cause tissue damage and oxidative stress in aquatic animals, thereby inhibiting their growth and even threatening their survival. This has become a key factor limiting the utilization of saline-alkaline water resour...
2026-04-18 | MTBLS14311 | MetaboLights
TranscriptomicsInhibition of Hedgehog Signaling Pathway Impairs Cancer Cell Growth via Promotion of Autophagy
Analysis of gene expression levels in response to inhibition of Hh signaling in ovarian and glioma cancer cells using a cDNA microarray technique. Microarray analyses revealed that differentially expressed genes (DEGs) in human cancer cells are enriched in the senescence and autophagy pathways in re...
ORGANISM(S): Homo sapiens 
2014-06-15 | E-GEOD-54936 | biostudies-arrayexpress
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