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ProteomicsMulti-Omics Analyses Revealed Conserved Aging Signatures in Mice
Studies on aging have largely included one or two OMICS layers, which may not necessarily reflect the signatures of other layers. Moreover, most aging studies have often compared very young (4-5 wks) mice with old (24 months) mice which does not reflect the aging transition after the attainment of a...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-30 | PXD011142 | Pride
Mouse tissue aging 
ProteomicsQuantitative proteomics of PWK/PhJ liver and heart tissues
Proteomic analysis of liver and heart tissues from PWK/PhJ mice, both male and female mice on a standard Chow diet (CD) and Western Diet (WD).
ORGANISM(S): Mus musculus (Mouse) 
2026-04-20 | PXD068560 | Pride
ProteomicsQuantitative proteomics of PWK/PhJ liver and heart tissues
Proteomic analysis of liver and heart tissues from PWK/PhJ mice, both male and female mice on a standard Chow diet (CD) and Western Diet (WD)
ORGANISM(S): Mus musculus (Mouse) 
2026-04-20 | PXD068595 | Pride
Boxcar lc-ms/ms Liver Heart 
TranscriptomicsMolecular mechanisms underlying the metabolic changes induced by the Pro12Ala PPARγ2 variant in mice
The metabolic impact of the common peroxisome proliferator-activated receptor gamma isoform 2 (PPARγ2) variant Pro12Ala in human populations has been widely debated. We demonstrate using a Pro12Ala knock-in model that on chow Ala/Ala mice are leaner, have improved insulin sensitivity and plasma lip...
ORGANISM(S): Mus musculus 
2010-06-25 | E-GEOD-13305 | biostudies-arrayexpress
GenomicsNCoR Repression of LXRs Restricts Macrophage Biosynthesis of Insulin-Sensitizing Omega 3 Fatty Acids
Macrophage-mediated inflammation is a major contributor to obesity-associated insulin resistance. The corepressor NCoR interacts with inflammatory pathway genes in macrophages, suggesting that its removal would result in increased activity of inflammatory responses. Surprisingly, we find that macrop...
ORGANISM(S): Mus musculus 
2013-10-09 | E-GEOD-50944 | biostudies-arrayexpress
TranscriptomicsCalorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans
Resveratrol is a naturally occurring compound that profoundly affects energy metabolism and mitochondrial function and serves as a calorie restriction mimetic, at least in animal models of obesity. Here we treated 10 healthy, obese men with placebo and 150 mg/day resveratrol in a randomized double-b...
ORGANISM(S): Homo sapiens 
2011-11-08 | E-GEOD-32357 | biostudies-arrayexpress
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