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TranscriptomicsTranscription profiling of brain samples from human control and schizophrenia patients who were treated with either typical, atypical or no antipsychotic medication
Multiple studies have shown that brain gene expression is disturbed in subjects suffering from schizophrenia. However, disentangling disease effects from alterations caused by neuroleptics is a challenging task.
To address the issues of disease heterogeneity and the effect of antipsychotic medi...
ORGANISM(S): Homo sapiens 
2007-12-06 | E-MEXP-857 | biostudies-arrayexpress
GenomicsEssential role of EBF1 in B cell immunity by controlling the generation and function of distinct mature B cell types
The transcription factor EBF1 is essential for lineage specification in early B cell development. Here we demonstrate by conditional mutagenesis that EBF1 was required for B cell commitment, pro-B cell development and subsequent transition to pre-B cells. Later in B cell development, EBF1 was essent...
ORGANISM(S): Mus musculus 
2012-03-20 | E-GEOD-35857 | biostudies-arrayexpress
TranscriptomicsStage-specific control of early B cell development by the transcription factor Ikaros
Ikaros is an essential regulator of lymphopoiesis. Here, we studied the B-cell-specific function of Ikaros by conditional Ikzf1 inactivation in pro-B cells. B-cell development was arrested at an aberrant ‘pro-B’ cell stage characterized by increased cell adhesion and loss of pre-B cell receptor sign...
ORGANISM(S): Mus musculus 
2014-02-09 | E-GEOD-53595 | biostudies-arrayexpress
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