Axon degeneration

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Modification

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Study type

Transcription profiling by array (76)
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Animal - High-throughput sequencing (1)
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Lab affiliation

CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai 200032, China (2)
DZNE Munich Neuroproteomics Feodor-Lynen Str. 17 81377 Munich Germany (1)
Department of Biological Sciences Rutgers University Newark (1)
Department of Biology, Stanford University, Stanford, CA, 94305 (1)
Department of Chemistry, Scripps Research (1)
Department of Neurobiology, Harvard Medical School; Boston, USA. (1)
Department of Ophthalmology, University of Cologne (1)
Department of Translational Medicine – Hand Surgery, Lund University, Malmö, Sweden (1)
Kobilka Institute of Innovative Drug Discovery, School ofMedicine, The Chinese University of Hong Kong, Shenzhen, China, 518172 (1)
PD Dr. Olaf Jahn Proteomics Group Max-Planck-Institute of Experimental Medicine Hermann-Rein-Str. 3 37075 Goettingen, Germany Tel: +49-551-3899313 Fax: +49-551-3899323 E-mail: jahn@em.mpg.de URL: www.em.mpg.de/proteomics (1)
TIGEM (1)
University of Southampton (1)

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Structural plasticity of actin-spectrin membrane skeleton and functional role of actin and spectrin in axon degeneration

Axon degeneration sculpts precise patterns of connectivity in the developing nervous system and is an early pathological hallmark of several adult-onset neurodegenerative disorders. Substantial progress has been made in identifying effector mechanisms that drive axon fragmentation, but far less is k...

ORGANISM(S): Mus musculus (Mouse)

2019-03-14 | PXD009854 | Pride

ProNGF elicits retrograde axonal degeneration of basal forebrain neurons via p75NTR and induction of APP

Basal forebrain cholinergic neurons (BFCNs) extend long projections to multiple targets in the brain to regulate cognitive functions, and are compromised in numerous neurodegenerative disorders. Our previous study showed that injury to the target region of these neurons affects their viability in vi...

ORGANISM(S): Rattus norvegicus (Rat)

2025-05-06 | PXD043846 | Pride

Key words: proneurotrophin Axon degeneration P75ntr Axonal protein synthesis

Transcription profiling of Drosophila mushroom body neurons at the onset and early steps of axon pruning

Drosophila mushroom body (MB) Î³ neurons undergo axon pruning during metamorphosis through a process of localized degeneration of specific axon branches. Developmental axon degeneration is initiated at the onset of metamorphosis by the pre-pupal rise in the steroid hormone ecdysone. This study ide...

ORGANISM(S): Drosophila melanogaster

2008-06-18 | E-GEOD-10012 | biostudies-arrayexpress

Multi-kinase inhibition of STE20 kinases is neuroprotective against chemotherapy-induced axon degeneration

PRJNA1269058 | ENA

Transcriptome analysis of neuromuscular junction during degeneration and regeneration of axon terminal

The neuromuscular junction (NMJ) is a specialized tripartite synapse composed of the motor axon terminal, covered by perisynaptic Schwann cells (PSCs), and the muscle fibre, separated by a basal lamina. It is exposed to different kind of injures such as mechanical traumas, pathogens including neurot...

ORGANISM(S): Mus musculus

2017-05-30 | E-MTAB-5730 | biostudies-arrayexpress

Macrophages protect against sensory axon degeneration in diabetic neuropathy

PRJNA1075431 | ENA

Genetically perturbed myelin as a risk factor for neuroinflammation-driven axon degeneration

PRJNA929453 | ENA

Rac1 impairs retinal axon degeneration via Kif2a in a mouse model of chronic ocular hypertension

PRJNA1040182 | ENA

Distinct pathways mediate axon degeneration during apoptosis and axon-specific pruning.

Not available

S-EPMC4183061 | biostudies-literature

Transcriptome analysis of neuromuscular junction during degeneration and regeneration of axon terminal