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TranscriptomicsTranscription profiling of rat bladder after inoculation with bladder cancer cells
Rat bladder cancer cells (AY-27 cell line) were inoculated intravesically into syngeneic female Fischer rats. The bladder was analyzed by histology and Affymetrix GeneChips and compared to bladders from sham operated and normal rats.
ORGANISM(S): Rattus norvegicus 
2009-04-22 | E-MTAB-104 | biostudies-arrayexpress
TranscriptomicsLate life rapamycin treatment reverses age-related heart dysfunction
We report the mRNA profile of aged mice (24 months old) fed either a control diet or a diet containing Rapamycin (14 ppm) for 3 months. After drug treatement, the hearts of the mice were removed and total mRNA was removed from the tissue. Analysis revealed that there were 700 significantly different...
ORGANISM(S): Mus musculus 
2013-07-01 | E-GEOD-48043 | biostudies-arrayexpress
TranscriptomicsRapamycin extends life span, but has limited effects on aging in mice
Rapamycin extends life span in mice, but it remains unclear if this compound also delays mammalian aging. Here, we present results from a comprehensive large-scale assessment of a wide rage of structural and functional aging phenotypes in mice. Rapamycin extended life span but showed few effects on ...
ORGANISM(S): Mus musculus 
2013-07-29 | E-GEOD-41018 | biostudies-arrayexpress
TranscriptomicsEffect of Sirolimus treatment on lupus nephritis in NZB/W F1 female mice
NZB/WF1 female mice spontaneously develop autoimmune lupus nephritis. Expression profiling of kidney tissue from (a) 12 week NZB/W F1 female mice defined as asymptomatic for lupus nephritis, (b) 36 and 42 week NZB/W F1 female mice defined as diseased/symptomatic for lupus nephritis and (c) 36 and 42...
ORGANISM(S): Mus musculus 
2008-11-20 | E-GEOD-12024 | biostudies-arrayexpress
TranscriptomicsSirolimus induced phosphaturia
Introduction: The kidney is the major arbiter of extracellular phosphate homeostasis. The vast majority of glomerular filtrated phosphate is reabsorbed in the proximal tubule. Posttransplant phosphaturia is common and aggravated by sirolimus immunosuppression. The cause of sirolimus induced phosphat...
ORGANISM(S): Rattus norvegicus 
2012-09-24 | E-GEOD-35048 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CEM-C1 cells treate with rapamycin for 3 hours
Drug resistance remains a major obstacle to successful cancer treatment. Here we use a novel approach to identify rapamycin as a glucocorticoid resistance reversal agent. A database of drug-associated gene expression profiles was screened for molecules whose profile overlapped with a gene expression...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-5822 | biostudies-arrayexpress
TranscriptomicsGene expression data from rapamycin resistant and sensitive cell lines
The mammalian target of rapamycin (mTOR) is a central regulator of cell proliferation. Inhibitors of mTOR are being evaluated as anti-tumor agents. Given the emerging role of microRNAs (miRNAs) in tumorgenesis we hypothesized that miRNAs could play important roles in the response of tumors to mTOR i...
ORGANISM(S): Mus musculus 
2013-02-08 | E-GEOD-19885 | biostudies-arrayexpress
TranscriptomicsDe novo kidney transplantation without use of calcineurin inhibitors preserves renal structure and function
Background: Despite significant improvements in short-term kidney transplant survival, comparable increases in 5 and 10-year outcomes have not been achieved. Chronic allograft nephropathy (CAN) is a major cause of late graft loss. Toxic nephropathy and inadequate long-term immunosuppression are poss...
ORGANISM(S): Homo sapiens 
2004-09-23 | E-GEOD-1743 | biostudies-arrayexpress
TranscriptomicsShort-term rapamycin treatment in mice have few effects on the transcriptome of white adipose tissue compared to dietary restriction
Analysis of the transcriptome in the epididymal fat of young mice (8 months of age) from treatment of dietary restriction, or rapamycin Total RNA extracted from epididymal fat of 8 month old C57BL6/J mice started on ad libitum (AL) , 40% dietary restriction (DR), or 14 ppm rapamycin (Rapa) from 2 mo...
ORGANISM(S): Mus musculus 
2014-08-18 | E-GEOD-52825 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CEM_C1 cells after rapamycin treatment of 24 hours
Drug resistance remains a major obstacle to successful cancer treatment. Here we use a novel approach to identify rapamycin as a glucocorticoid resistance reversal agent. A database of drug-associated gene expression profiles was screened for molecules whose profile overlapped with a gene expression...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-5821 | biostudies-arrayexpress
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