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ProteomicsA proteomic study of the dual oncogenic and tumor- suppressive roles of SIRT3 in lung and breast cancer cell lines
The mitochondria play a crucial role in metabolism and energy production by generating adenosine triphosphate (ATP) through oxidative phosphorylation. Additionally, they are involved in maintaining intracellular calcium levels, facilitate nuclear communication, detoxify reactive oxygen species (ROS)...
ORGANISM(S): Homo sapiens (Human) 
2026-02-16 | PXD063181 | Pride
Mitochondria  cancer  post-translational modification  acetylation  sirtuin  metabolism  oxidative phosphorylation 
ProteomicsDynamics of Mitochondrial Proteome and Acetylome in Glioblastoma Cells with Contrasting Metabolic Phenotypes
The dysregulated energy metabolism of glioblastoma cells is a critical factor in tumor development and progression. Lysine acetylation, regulated by the mitochondrial enzyme SIRT3, is known to play a key role in the metabolic phenotype of glioblastoma. To better understand how SIRT3 regulates mitoch...
ORGANISM(S): Homo sapiens (Human) 
2024-05-23 | PXD045197 | Pride
Metabolism Lysine acetylation Sirt3 Glioblastoma Mitochondria 
UnknownChild and Adolescent Health From 1990 to 2015: Findings From the Global Burden of Diseases, Injuries, and Risk Factors 2015 Study.
Not available
S-EPMC5540012 | biostudies-literature
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