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MetabolomicsSIRT3-dependent glutaminolysis enhances germinal center epigenetic programming through α-ketoglutarate

Germinal center (GC) B cells depend on sustained epigenetic modulation to maintain transcriptional identity and support affinity maturation; however, whether mitochondrial metabolism directly enhances this chromatin state remains unclear. Here, we show that enhanced SIRT3 activity promotes glutam...

2026-09-04 | MTBLS15385 | MetaboLights
GenomicsSIRT3 functions in the nucleus in the control of stress-related gene expression.
SIRT3 is a member of the Sir2 family of NAD+-dependent protein deacetylases that promotes longevity in many organisms. The processed, short form of SIRT3 is a well-established mitochondrial protein whose deacetylase activity regulates various metabolic processes. However, the presence of full-length...
ORGANISM(S): Homo sapiens 
2012-10-16 | E-GEOD-41000 | biostudies-arrayexpress
TranscriptomicsSIRT3 opposes metabolic reprogramming of cancer cells through HIF1a destabilization
Tumor cells exhibit aberrant metabolism characterized by high glycolysis even in the presence of oxygen. This metabolic reprogramming, known as the Warburg effect, provides tumor cells with the substrates and redox potential required for the generation of biomass. Here, we show that the mitochondria...
ORGANISM(S): Mus musculus 
2011-03-15 | E-GEOD-27309 | biostudies-arrayexpress
ProteomicsNuclear SIRT3 counteracts human stem cell senescence
Sirtuin 3 (SIRT3) is an NAD+-dependent deacetylase involved in various physiological and pathological processes. However, the role of SIRT3 in regulating human stem cell senescence remains largely unknown. Here, we observed the downregulated expression of SIRT3 in senescent human mesenchymal stem ce...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD023479 | Pride
Sirt3 stem cell aging lad 
ProteomicsDeficiency in Sirtuin3 rewires mitochondrial metabolism and increases maximum lifespan under caloric restriction - Mitochondrial Acetylation Stoichiometry
Quantification of acetylation stoichiometry from mitochondrial enriched proteins from mouse livers. Conditions compared include genotype, diet, and age; i.e. Sirt3 KO vs Sirt3 WT, caloric restricted (CR) diet vs control diet (CD), and 5 months old vs 25 months old.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-03-23 | MSV000087085 | MassIVE
ProteomicsSIRT3 interactions and mitochondrial proteome during HCMV infection
SIRT3 has been shown to inhibit HCMV infection, but the mechanism under the antiviral effect is not clear. To identify the mediator of SIRT3 antiviral function, we aim to identify and quantify SIRT3 interactions during HCMV infection. A set of large-scale IPs were performed to determine the specific...
ORGANISM(S): Homo sapiens (Human) 
2021-04-01 | PXD018995 | Pride
Hcmv Mitochondrial proteome Ip-ms Sirt3 
ProteomicsRemodelling of the acetylproteome by SIRT3 manipulation fails to affect insulin secretion or beta-cell metabolism in the absence of over nutrition
From Peterson et. al. 2018: SIRT3 is an NAD+-dependent mitochondrial protein deacetylase purported to influence metabolism through post-translational modification of metabolic enzymes. Fuel-stimulated insulin secretion, which involves mitochondrial metabolism, could be susceptible to SIRT3-mediated...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-06-21 | PXD009509 | Pride
Pancreas Protein acetylation Beta cells Sirt3 
ProteomicsSIRT3 Deacetylates TFAM to Promote Mitochondrial Biogenesis
SIRT3 is a NAD+-dependent mitochondrial protein deacetylase participating in the regulation of central metabolism and mitochondrial proteostasis. SIRT3 is downregulated in clear cell renal cell carcinoma (ccRCC), a main type of renal cancers, but the function of SIRT3 in tumorigenesis and developmen...
ORGANISM(S): Homo sapiens (Human) 
2018-08-14 | PXD009110 | Pride
Proteomics Sirt3 Mitochondrial biogenesis Clear cell renal cancer Tfam acetylation 
ProteomicsAnalysis of acetylation stoichiometry suggests that SIRT3 repairs nonenzymatic acetylation lesions
Acetylation is frequently detected on mitochondrial enzymes and the sirtuin deacetylase SIRT3 is thought to regulate metabolism by deacetylating mitochondrial proteins. However, the stoichiometry of acetylation has not been studied and is important for understanding whether SIRT3 regulates or suppre...
ORGANISM(S): Mus musculus (Mouse) 
2015-09-15 | PXD000885 | Pride
Sirt3 Stoichiometry Acetylation Liver 
TranscriptomicsExpression data from mice lacking SIRT3 under dietary stress
SIRT3 is a mitochondrial NAD(+)-dependent protein deacetylase, which regulates the enzymatic activity of several mitochondrial proteins. We used microarrays to identify the differences in gene expression as a result of loss of SIRT3, under standard and high-fat diet conditions Wild-type and SIRT3KO ...
ORGANISM(S): Mus musculus 
2011-07-11 | E-GEOD-30552 | biostudies-arrayexpress
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