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TranscriptomicsHigh-resolution profiling and analysis of viral and host small RNAs during human cytomegalovirus infection
Small RNA deep sequencing analysis was conducted on primary human fibroblasts infected with human cytomegalovirus (HCMV). HCMV-encoded miRNAs accumulated to ~20% of the total smRNA population at late stages of infection, and our analysis led to improvements in viral miRNA annotations and identificat...
ORGANISM(S): Homo sapiens 
2011-11-10 | E-GEOD-33584 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human HCMV-Infected monocytes study 2
Human cytomegalovirus induces a pro-inflammatory monocyte following infection. To begin to address how HCMV induces these rapid changes in infected monocytes, we examined the transcriptome of infected monocytes. Global transcriptional profiling using cDNA microarrays revealed a significant number ...
ORGANISM(S): Homo sapiens 
2008-06-20 | E-GEOD-11408 | biostudies-arrayexpress
TranscriptomicsRNA-Induced Silencing Complex-associated RNA in MRC-5 cells transfected with hcmv-miR-UL22A-5p
Investigation of mRNA targets of the human cytomegalovirus miRNA UL22A-5p One 4-plex chip was hybridized with cDNA originating from either total RNA or from AGO2-associated RNA (i.e. RISC-associated RNA) from fibroblasts transfected 48 hours earlier with hcmv-miR-UL22A-5p mimic or with a negative co...
ORGANISM(S): Homo sapiens 
2015-04-08 | E-GEOD-64503 | biostudies-arrayexpress
TranscriptomicsExpression data from human memory CD4 T-cells stimulated with autologous monocytes pulsed with HCMV
The present study reports an unbiased analysis of the genetic profile and regulation of NKG2D expressing CD4 T-cells.An Affymetrix microarray analysis was used to explore the genetic profile of NKG2D+ versus NKG2D- CD4 T-cells. The genetic profile was studied by single gene analysis and gene set enr...
ORGANISM(S): Homo sapiens 
2012-08-14 | E-GEOD-33670 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human HCMV-Infected monocytes
Human cytomegalovirus induces a pro-inflammatory monocyte following infection and we have evidence that NF-κB and phosphatidylinositol 3-kinase [PI(3)K] are key mediators in this early activation. To begin to address how these signalling pathways are responsible for the rapid activation of infecte...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9601 | biostudies-arrayexpress
ProteomicsIdentification of novel canonical and cryptic HCMV-specific T cell epitopes
Infection or reactivation with human cytomegalovirus (HCMV) is still a major cause of morbidity and mortality in patients undergoing solid organ transplantation or allogeneic stem cell transplantation (alloSCT). Recent studies have shown that protection against latent HCMV infection relies on a much...
ORGANISM(S): Homo sapiens (Human) Cytomegalovirus 
2024-06-16 | PXD043022 | Pride
Hcmv Immunopeptidomics Hla peptides 
TranscriptomicsExpression Data From HCMV-Infected Human Monocytes: Role of EGFR
Human cytomegalovirus (HCMV) induces pro-inflammatory monocytes following infection and we have evidence that EGFR is a key mediator in this early activation. To begin to address how this signalling pathway is responsible for the rapid activation of infected monocytes, we examined the role this pat...
ORGANISM(S): Homo sapiens 
2009-09-03 | E-GEOD-17948 | biostudies-arrayexpress
TranscriptomicsDecoding human cytomegalovirus using ribosome profiling
The human cytomegalovirus (HCMV) genome was sequenced 20 years ago. However, like other complex viruses, our understanding of its protein coding potential is far from complete. Here, we use ribosome profiling and transcript analysis to experimentally define the HCMV translation products and follow t...
ORGANISM(S): Human Herpesvirus 5 
2012-10-17 | E-GEOD-41605 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CMV-stimulated CD69+, hCMV-stimulated CD69- and unstimulated monoclonal CD4+ T-LGL lymphocytes from peripheral blood samples from four TCRVbeta+/CD4+ T-LGL lymphocytosis patients
Recent studies suggest the potential involvement of common antigenic stimuli on the ontogeny of monoclonal TCRalphabeta+/CD4+/NKa+/CD8-/+dim T-large granular lymphocyte (LGL) lymphocytosis. Since healthy individuals show (oligo)clonal expansions of hCMV-specific TCRVbeta+/CD4+/cytotoxic/memory T-cel...
ORGANISM(S): Homo sapiens 
2008-10-25 | E-GEOD-12488 | biostudies-arrayexpress
TranscriptomicsHCMV infection of human neural precursor cells: Human neural precursor cell expression
HCMV -treated and control human adult neural precurso cells (NPC) were used to extract RNA for profiling on DNA arrays Primary adult hippocampus-derived neural precursor cells were used at passage # 2-4 for HCMV infection, followed by RNA extraction at indicated times Primary adult neural precursor ...
ORGANISM(S): Homo sapiens 
2012-07-21 | E-GEOD-30912 | biostudies-arrayexpress
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