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TranscriptomicsRNA expression analysis after DU-145 cell treatment with demethylating agent 5-Aza-2’-deoxycitidine (5-Aza)
Transcriptional profiling of DU-145 cells treated with 5-Aza for 72 h. Relative abundance to untreated control cells was used to estimate the effect of DNA demethylation on the expression of the RNAs. Two-condition experiment, 5-Aza-treated vs. untreated DU-145 cells. Biological replicates: 2. Techn...
ORGANISM(S): Homo sapiens 
2015-06-30 | E-GEOD-62955 | biostudies-arrayexpress
TranscriptomicsRNA expression analysis after MCF-7 cell treatment with demethylating agent 5-Aza-2’-deoxycitidine (5-Aza)
Transcriptional profiling of MCF-7 cells treated with 5-Aza for 96 h. Relative abundance to untreated control cells was used to estimate the effect of DNA demethylation on the expression of the RNAs. Two-condition experiment, 5-Aza-treated vs. untretated MCF-7 cells. Biological replicates: 2. Techni...
ORGANISM(S): Homo sapiens 
2015-06-30 | E-GEOD-62958 | biostudies-arrayexpress
TranscriptomicsRNA expression analysis after Mia PaCa 2 cell treatment with demethylating agent 5-Aza-2’-deoxycitidine (5-Aza)
Transcriptional profiling of Mia PaCa 2 cells treated with 5-Aza for 96 h. Relative abundance to untreated control cells was used to estimate the effect of DNA demethylation on the expression of the RNAs. Two-condition experiment, 5-Aza-treated vs. untretated Mia PaCa 2 cells. Biological replicates:...
ORGANISM(S): Homo sapiens 
2015-06-30 | E-GEOD-62959 | biostudies-arrayexpress
GenomicsAza
Targeted bisulfite sequencing
EGAD00010000868 | EGA
TranscriptomicsIntragraft transcriptional profiling of renal transplant patients with tubular dysfunction after distinct immunosuppressive regimens
Intragraft transcriptional profiles were investigated in patients with tubular dysfunction to disclose subclinical mechanisms underlying graft deterioration. Moreover, we analyzed whether individualization of immunosuppression could modify this profile while improving renal function after 12 months ...
ORGANISM(S): Homo sapiens 
2015-07-31 | E-GEOD-48250 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of mouse gene expression in metronomic cyclophosphamide-treated rat glioma 9L xenografts implanted in scid mice
Cyclophosphamide (CPA) treatment on a six-day repeating metronomic schedule induces a dramatic, innate immune cell-dependent regression of implanted gliomas. However, little is known about the underlying mechanisms of innate immune cell mobilization and recruitment, or about the role of DNA damage a...
ORGANISM(S): Rattus norvegicus 
2015-05-04 | E-GEOD-60864 | biostudies-arrayexpress
TranscriptomicsIdentification of mechano- and/or 5Aza-sensitive genes in mouse carotid artery endothelium in vivo exposed to disturbed blood flow for 7 days
Atherosclerosis preferentially occurs in arterial regions of disturbed blood flow (d-flow), which alters gene expression, endothelial function, and atherosclerosis. Here, we show that d-flow regulates genome-wide DNA methylation patterns in a DNA methyltransferase (DNMT)-dependent manner. D-flow ind...
ORGANISM(S): Mus musculus 
2014-03-25 | E-GEOD-56143 | biostudies-arrayexpress
GenomicsHigh resolution transcriptome-wide RNA cytosine methylome of Mouse Embryonic Fibroblasts
We report high resolution transcriptome-wide RNA cytosine methylome of Mouse Embryonic Fibroblasts (MEFs) revealed by an optimized new RNA bisulfite sequencing approach. Comparison of RNA methylation profile from wild-type and Dnmt2 -/- MEFs shows that only C38 in three tRNAs (tRNA-Asp, Gly and Val...
ORGANISM(S): Mus musculus 
2013-04-21 | E-GEOD-44359 | biostudies-arrayexpress
GenomicsData from the paper Context-specific Effects of TGFβ/SMAD3 in Cancer Are Modulated by the Epigenome. Tufegdzic et al, Cell Reports 2015
The transforming growth factor beta (TGFβ) signalling pathway exerts opposing effects on cancer cells, acting either as a tumor-promoter or as a tumor-suppressor. Here we show these opposing effects are a result of the synergy between SMAD3, a downstream effector of TGFβ signalling, and the distinct...
EGAS00001001570 | EGA
UnknownGenistein reverses hypermethylation and induces active histone modifications in tumor suppressor gene B-Cell translocation gene 3 in prostate cancer.
Not available
S-EPMC3954042 | biostudies-literature
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