Sort   by:  
 Page size 
Transcriptomics5-azacytidine treatment reorganizes genomic histone modification patterns
Methylation of DNA in combination with histone modifications establishes an epigenetic code that ensures the proper control of gene expression. Although DNA methyltransferases have been shown to interact with histone methyltransferases such as EZH2 (which methylates histone H3 on lysine 27) and G9a ...
ORGANISM(S): Homo sapiens 
2010-04-09 | E-GEOD-20598 | biostudies-arrayexpress
GenomicsWhole exome sequencing of human MDS/AML OCI-M2 and patient-derived bone marrow cell lines treated with 5-azacytidine
The whole exome sequencing experiment is part of the study: “Analysis of 5-azacytidine resistance models reveals a set of targetable pathways”. In the study we generated myelodysplastic syndrome/acute myeloid leukemia (MDS/AML) OCI-M2 cell lines as well as patient-derived bone marrow cell lines that...
ORGANISM(S): Homo sapiens 
2022-05-02 | E-MTAB-11172 | biostudies-arrayexpress
TranscriptomicsRNAseq to investigate transcriptional changes in human MM cell lines due to panobinostat, 5-Azacytidine, panobinostat+5-Azacytidine or n-methyl-2-pyrroldine (NMP) treatments.
Purpose: We applied RNA sequencing technology for high-throughput analysis of transcriptional changes within human MM cell lines JJN3 and U266 due to individual and combination drug treatment. Methods: JJN3 and U266 cells were treated with pan-HDACi panbobinostat, DNMTi 5-Azacytidine, panobinostat+5...
ORGANISM(S): Homo sapiens 
2014-04-09 | E-GEOD-56623 | biostudies-arrayexpress
TranscriptomicsTranscriptomic profiling of Aspergillus flavus in response to 5-azacytidine & gallic acid
Aspergillus flavus is a common saprophyte and opportunistic pathogen producing aflatoxin (AF) and many other secondary metabolites. 5-Azacytidine (5-AC), a derivative of nucleoside cytidine, is widely used for studies in epigenetics and cancer biology as an inactivator of DNA methyltransferase and i...
ORGANISM(S): Aspergillus flavus 
2013-06-15 | E-GEOD-40202 | biostudies-arrayexpress
GenomicsChIP-seq INA-6
Multiple myeloma (MM) cell line treated with an inhibitor to EZH2/EZH1 (UNC1999), DNA methylation inhibitor (5-azacytidine), and a combination of both.
ORGANISM(S): Homo sapiens 
2025-12-29 | E-MTAB-14627 | biostudies-arrayexpress
TranscriptomicsEffect of 5-azacytidine on gene expression in C2C12 myoblasts
Mesenchymal progenitor cells can be differentiated in vitro into myotubes that exhibit many characteristic features of primary mammalian skeletal muscle fibers. However, in general, they do not show the functional excitation-contraction coupling or the striated sarcomere arrangement typical of matur...
ORGANISM(S): Mus musculus 
2012-01-01 | E-GEOD-30192 | biostudies-arrayexpress
TranscriptomicsMethylation profiling by array of human cell line HCT116 after treatment with demethylating drugs azacytidine or decitabine.
array-based analysis of genome-wide DNA methylation changes induced by the demethylating drugs azacytidine and decitabine on HCT116 cells for 24 hours
ORGANISM(S): Homo sapiens 
2010-07-01 | E-MTAB-210 | biostudies-arrayexpress
TranscriptomicsMethylation profiling by array of human HCT116 and HL60 cells treated with the demthylating drugs azacytidine and decitabine
Array-based analysis of genome-wide DNA methylation changes induced by the demethylating drugs azacytidine and decitabine on HCT116 and HL60 cells for 24 hours
ORGANISM(S): Homo sapiens 
2010-12-01 | E-MTAB-417 | biostudies-arrayexpress
Transcriptomics5-azacytidine and entinostat treatment of patients with MDS, chronic myelomonocytic leukemia (CMMoL), and high risk AML
Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies. The patients with MDS, chronic myelomonocytic leukemia (CMMoL), and high risk AML were treated with sequential administration of ...
ORGANISM(S): Homo sapiens 
2009-06-20 | E-GEOD-16625 | biostudies-arrayexpress
TranscriptomicsRNA-seq of SUPT1, LOUCY, JURKAT and DND41 after treatment with 5-azacytidine and Vitamin C
TET2 is a know tumorsuppressor gene involved in the demethylation of DNA. TET2 catalyses the conversion of 5-methyl cytosine (5-mC) to 5-hydroximethyl cytosine (5-hmC), an important step in the removal of methylation from the DNA. In T-All mutations in TET2 are rare, however we have found that it is...
ORGANISM(S): Homo sapiens 
2021-08-04 | E-MTAB-10512 | biostudies-arrayexpress
Sort   by:  
 Page size