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ProteomicsAZD4573 is a highly selective CDK9 inhibitor that suppresses Mcl-1 and induces apoptosis in hematological cancer cells
Phosphorylation of RNA polymerase II by cyclin-dependent kinase 9 (CDK9) is crucial for transcriptional regulation, and acute inhibition of CDK9 results in the rapid downregulation of genes with short-lived transcripts and labile proteins. Multiple non-selective CDK9 inhibitors have progressed clini...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD013796 | Pride
A selective cdk9 inhibitor Azd4573 Targets mcl-1 
GenomicsCDK9 inhibition with AZD4573 in DLBCL
CDK9 inhibition with AZD4573 in DLBCL
PRJNA817183 | ENA
GenomicsCDK9 inhibition with AZD4573 in DLBCL
CDK9 inhibition with AZD4573 in DLBCL
PRJNA865376 | ENA
GenomicsCDK9 inhibition with AZD4573 in DLBCL
We report the effects of CDK9 inhibition (AZD4573) on the epigenetic landscape in Diffuse Large B-cell Lymphoma (DLBCL). This study utilized the Assay for Transposase-Accessible Chromatin with high-throughput sequencing (ATAC-seq) to assess genome-wide chromatin accessibility in two DLBCL cell lines...
ORGANISM(S): Homo sapiens 
2022-03-21 | GSE198851 | GEO
GenomicsCDK9 inhibition with AZD4573 in DLBCL
We report the effects of CDK9 inhibition (AZD4573) on the epigenetic landscape in Diffuse Large B-cell Lymphoma (DLBCL). This study utilized chromatin immunoprecipitation with massively parallel DNA sequencing (ChIP-seq) to assess genome-wide post-translational histone modifications (H3K27ac and H3K...
ORGANISM(S): Homo sapiens 
2022-08-05 | GSE210372 | GEO
TranscriptomicsRNA-seq data corresponding to: AZD4573 is a highly selective CDK9 inhibitor that suppresses Mcl-1 and induces apoptosis in hematological cancer cells
A time-course RNA-seq experiment testing the effect of drug treatment using selective CDK9 inhibitor AZD4573. The experiment was done using a resistant cell-line to AZD4573: the MCF7 breast cancer cell-line.
ORGANISM(S): Homo sapiens 
2019-11-08 | GSE129012 | GEO
GenomicsRNA-seq data corresponding to: AZD4573 is a highly selective CDK9 inhibitor that suppresses Mcl-1 and induces apoptosis in hematological cancer cells
RNA-seq data corresponding to: AZD4573 is a highly selective CDK9 inhibitor that suppresses Mcl-1 and induces apoptosis in hematological cancer cells
PRJNA529703 | ENA
TranscriptomicsTranscriptomic effects of combined AZD4573 and SMAP-2 treatment in resting and anti-CD3/CD28-activated primary human CD4+ T cells
This study characterized the effects of combined CDK9 inhibition and PP2A activation on host gene expression in primary human CD4+ T cells. In the broader study, the CDK9 inhibitor AZD4573 and the PP2A activator SMAP-2 cooperatively suppressed HIV transcription and promoted durable transcriptional s...
ORGANISM(S): Homo sapiens 
2026-08-05 | GSE342431 | GEO
GenomicsTranscriptomic effects of combined AZD4573 and SMAP-2 treatment in resting and anti-CD3/CD28-activated primary human CD4+ T cells
Transcriptomic effects of combined AZD4573 and SMAP-2 treatment in resting and anti-CD3/CD28-activated primary human CD4+ T cells
PRJNA1507849 | ENA
TranscriptomicsCyclin-dependent kinase-9 and oxidative phosphorylation inhibition overcome ibrutinib resistance in mantle cell lymphoma
Resistance to Bruton tyrosine kinase inhibitors (BTKi) is inevitable in mantle cell lymphoma (MCL). Cyclin-dependent kinase-9 (CDK9), a key regulator of oncogenic transcription, is a promising therapeutic target. Here we studied a selective CDK9 inhibitor, AZD4573, in MCL. AZD4573 suppressed growth ...
ORGANISM(S): Homo sapiens 
2026-04-10 | GSE327598 | GEO
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