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TranscriptomicsKras mutant v WT with or without AZD6244 in vivo study
HCT116 (kRas mt) cells and HKH2 (Kras wt) cells were implanted into the right and left flanks of nude mice and either untreated or treated with a MEK inhibitor (AZD6244) over time. Tumours were excised and harvested for RNA extraction at the end of the experiment and hybridised to the Colorectal DS...
ORGANISM(S): Homo sapiens 
2012-04-30 | E-MEXP-3557 | biostudies-arrayexpress
ClinicalPhase II Efficacy Study of AZD6244 in Colorectal Cancer
The purpose of the study is to assess if there is benefit when using AZD6244 in the treatment if metastatic colorectal cancer in comparison with another treatment called capecitabine. This study will also assess how safe and well tolerated AZD6244 is.
2043100 | ecrin-mdr-crc
TranscriptomicsSynergistic anti-tumor activity by association of MEK and PI3K/mTOR blockade with TRAIL in human melanoma
Combining direct anti-tumor effects with targeting of tumor microenvironment is an attractive strategy that may lead to more effective therapies for advanced melanoma. Here, we tested whether association of TRAIL with co-targeting of MEK and PI3K/mTOR, or with MEK blockade, could have synergistic a...
ORGANISM(S): Homo sapiens 
2014-10-08 | E-GEOD-55050 | biostudies-arrayexpress
UnknownPharmacokinetics and pharmacodynamics of AZD6244 (ARRY-142886) in tumor-bearing nude mice.
Not available
S-EPMC4332869 | biostudies-literature
UnknownInitial testing (stage 1) of AZD6244 (ARRY-142886) by the Pediatric Preclinical Testing Program.
Not available
S-EPMC3004092 | biostudies-literature
UnknownTargeting inhibition of extracellular signal-regulated kinase kinase pathway with AZD6244 (ARRY-142886) suppresses growth and angiogenesis of gastric cancer.
Not available
S-EPMC4644956 | biostudies-literature
UnknownThe novel anti-MEK small molecule AZD6244 induces BIM-dependent and AKT-independent apoptosis in diffuse large B-cell lymphoma.
Not available
S-EPMC3148157 | biostudies-literature
UnknownBasal and treatment-induced activation of AKT mediates resistance to cell death by AZD6244 (ARRY-142886) in Braf-mutant human cutaneous melanoma cells.
Not available
S-EPMC4286702 | biostudies-literature
UnknownIn vitro and in vivo radiosensitization with AZD6244 (ARRY-142886), an inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 kinase.
Not available
S-EPMC2798161 | biostudies-literature
UnknownA Phase II Trial of AZD6244 (Selumetinib, ARRY-142886), an Oral MEK1/2 Inhibitor, in Relapsed/Refractory Multiple Myeloma.
Not available
S-EPMC4775365 | biostudies-literature
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