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Administration of azithromycin after allogeneic hematopoietic stem cell transplantation for hematological malignancies has been associated with relapse in a randomized phase 3 controlled clinical trial. Studying 240 samples from patients randomized in this trial is a unique opportunity to better und...
2022-08-22 | MTBLS406 | MetaboLights
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ORGANISM(S): Plasmodium falciparum 
Microarrays were used to evaluate the effects of azithromycin and an inflammatory stimulus (SMM) on human airway epithelium. Effects of azithromycin treatment were evaluated at 6, 24 and 48 hours. Effects of SMM were evaluated at 6 and 24 hours. In addition, pretreatment with azithromycin was used t...
ORGANISM(S): Homo sapiens 
Experimental Design; Type of experiment:; In order to evaluate the influence of subinhibitory concentrations of the macrolide antibiotic Azithromycin (AZM) on the global Pseudomonas aeruginosa gene expression, we performed a comparative gene expression analysis of AZM-treated versus untreated P. aer...
ORGANISM(S): Pseudomonas aeruginosa 
We sequenced a total of 12 cDNA libararies derived from fragmented total mRNA and ribosome protected mRNAs from azithromycin-treated and -untreated S. aureus samples. The data represented 2 independent biological replicates. Examination of the impact of azithromycin on global translatome, mRNA abund...
ORGANISM(S): Staphylococcus aureus subsp. aureus NCTC 8325 
Cellular thermal shift performed on cell lysates as well as in cellulo with P. falciparum 3D7 cell lines and three azithromycin analogs (GSK-66, UAW-1 and UAW-2) as isothermal dose response experiment.
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2025-06-19 | PXD055102 | Pride
Azithromycin has been shown to have anti-fibrotic effects on idiopathic lung fibroblasts (IPF). We thus wanted to investigate involved genes and pathways by microarray analysis. We treated normal human lung fibroblasts with Azithromycin (50uM) for 24h and compared them to non-treated samples.
ORGANISM(S): Homo sapiens 
Azithromycin (AZM) reduces pulmonary inflammation and exacerbations in chronic obstructive pulmonary disease patients with emphysema. The antimicrobial effects of AZM on the lung microbiome are not known and may contribute to its beneficial effects. Methods. Twenty smokers with emphysema were rando...
ORGANISM(S): human lung metagenome 
Azithromycin resistance Salmonella Typhi in India
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