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MetabolomicsGPR109a-AMPK Axis Mediates the Attenuation of Uric Acid-Induced M1 Macrophage Polarization by β-hydroxybutyrate from Lacticaseibacillus rhamnosus M2b

Hyperuricemia (HUA) is a metabolic disorder marked by increased blood uric acid (UA) levels, closely linked to conditions such as gout. UA-induced macrophage M1 polarization fundamentally exacerbates inflammatory pathophysiology, but current HUA-specific immunoregulatory treatments are inadequat...

2026-01-26 | MTBLS13224 | MetaboLights
TranscriptomicsGene Expression analysis of hESC B2M knock-out
The clinical use of human pluripotent stem cells and their derivatives is limited by the rejection of transplanted cells due to differences in their HLA genes. This has led to the proposed use of histocompatible, patient-specific stem cells, however the preparation of many different stem cell lines ...
ORGANISM(S): Homo sapiens 
2014-01-01 | E-GEOD-42289 | biostudies-arrayexpress
TranscriptomicsiPS2-10X-seq experiment on specific clones targeting with an shRNA either SMAD2 or B2M
We transfected hiPSCs WTC11 with specific shRNAs targeting SMAD2 or B2M. hiPSCs transfected were selected, cultured, and clones were picked and expanded for follow-up validations. Among these validations, we obtained this scRNAseq dataset. We cultured hiPSCs and differentiated them into cardiac orga...
ORGANISM(S): Homo sapiens 
2025-10-27 | E-MTAB-15307 | biostudies-arrayexpress
TranscriptomicsiPS2-CITE-seq with arrayed polyclonal hiPSC targeting of either SMAD2 or B2M
We transfected hiPSCs WTC11 with specific shRNAs targeting SMAD2 or B2M. hiPSCs transfected were selected, cultured, and four clones were selected per targeting and expanded for follow-up validations. We cultured hiPSC and differentiated them into cardiac organoids for 7.5 days. This experiment allo...
ORGANISM(S): Homo sapiens 
2025-10-27 | E-MTAB-15309 | biostudies-arrayexpress
GenomicsGene expression changes in HSV-1 infected HeLa cells with knockdown of B2M
Gene expression changes in HSV-1 infected HeLa cells with knockdown of B2M
PRJNA573645 | ENA
GenomicsiPS2-CITE-seq with arrayed polyclonal hiPSC targeting of either SMAD2 or B2M
iPS2-CITE-seq with arrayed polyclonal hiPSC targeting of either SMAD2 or B2M
PRJEB91674 | ENA
UnknownEfficient generation of B2m-null pigs via injection of zygote with TALENs.
Not available
S-EPMC5159787 | biostudies-literature
GenomicsTranscriptional profiling of tumor microenvironment in B2M KO CD40-treated B16 tumors implanted in mice
Transcriptional profiling of tumor microenvironment in B2M KO CD40-treated B16 tumors implanted in mice
PRJNA1002361 | ENA
TranscriptomicsGene expression changes in HSV-1 infected HeLa cells with knockdown of B2M
To understand the global effects of B2M knock-down on host gene expression, the RNA-seq study was carried out using HSV-1 infected HeLa cells transfected with B2M siRNAs (siB2M) or negative control siRNAs (siCTRL)
ORGANISM(S): Homo sapiens 
2019-09-24 | GSE137843 | GEO
UnknownB2M regulates ELANE in pyroptosis to affect pancreatic cancer progression.
Not available
S-EPMC12681877 | biostudies-literature
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