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UnknownPharmacokinetics, Safety, and Tolerability of Oxfendazole in Healthy Adults in an Open-Label Phase 1 Multiple Ascending Dose and Food Effect Study.
Not available
S-EPMC7577123 | biostudies-literature
TranscriptomicsTranscritpome analysis of Mycobacterium tuberculosis (Mtb) mutants deficient in ergothioneine, or mycothiol production
This experiment was performed to determine deferentially regulated genes in the absence of redox buffer ergothioneine (EGT), or mycothiol (MSH). We had used two Mtb mutants namely egtA:Tn and egtD:Tn which are deficient in EGT production ( Transposon Mutant of EGT biosynthesis pathway); In additi...
ORGANISM(S): Mycobacterium tuberculosis CDC1551 
2016-01-27 | E-MTAB-4099 | biostudies-arrayexpress
UnknownPharmacokinetics, Safety, and Tolerability of Oxfendazole in Healthy Volunteers: a Randomized, Placebo-Controlled First-in-Human Single-Dose Escalation Study.
Not available
S-EPMC6437481 | biostudies-literature
TranscriptomicsTranscription profiling of homozygous Commd1 null mouse embryos to elucidate the underlying mechanism leading to embryonic lethality
A gene expression study using microarray analysis was performed to elucidate the underlying mechanism leading to embryonic lethality in homozygous Commd1 null (Commd1-/-) mouse embryos. A gene expression profile of 9.5 dpc Commd1-/- embryos were generated and were compared to a gene expression profi...
ORGANISM(S): Mus musculus 
2006-09-01 | E-MEXP-832 | biostudies-arrayexpress
TranscriptomicsTranscriptional responses of Mycobacterium tuberculosis to lung surfactant
This study uses microarray analyses to examine gene expression profiles for Mycobacterium tuberculosis (Mtb) induced by exposure in vitro to bovine lung surfactant preparations that vary in apoprotein content: (i) whole lung surfactant (WLS) containing the complete mix of endogenous lipids and surfa...
ORGANISM(S): Mycobacterium tuberculosis 
2010-05-18 | E-GEOD-14005 | biostudies-arrayexpress
TranscriptomicsThe effect of Dis3 knockdown on miRNA expression in Drosophila wing imaginal discs.
We investigated the effect on miRNA expression in Drosophila melanogaster wing imaginal discs following the knockdown of the 3'-5' exoribonuclease Dis3.
ORGANISM(S): Drosophila melanogaster 
2015-06-01 | E-MTAB-3569 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profiles distinguish liposarcoma subtypes and implicate miR-145 and miR-451 as tumor suppressors (validation)
Liposarcomas are rare, heterogeneous and malignant tumors that can be divided into five histological subtypes with different characteristics and clinical behavior. Treatment consists of surgery in combination with systemic chemotherapy, but nevertheless mortality rates are high. More insight into th...
ORGANISM(S): Homo sapiens 
2014-03-01 | E-GEOD-45363 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profiles distinguish liposarcoma subtypes and implicate miR-145 and miR-451 as tumor suppressors (discovery)
Liposarcomas are rare, heterogeneous and malignant tumors that can be divided into five histological subtypes with different characteristics and clinical behavior. Treatment consists of surgery in combination with systemic chemotherapy, but nevertheless mortality rates are high. More insight into th...
ORGANISM(S): Homo sapiens 
2014-03-01 | E-GEOD-45359 | biostudies-arrayexpress
TranscriptomicsCharacterisation of Two New Th17-Subsets with Distinct Contribution to HIV-1 Persistence under Antiretroviral Therapy
Th17 cells act as the first line of defense against pathogens at mucosal surfaces. Their paucity during HIV infection causes disease progression. Here, we reveal the existence of two new CCR6+CD161+ subsets, CCR4-CXCR3- (DN; double negative) and CCR4+CXCR3+ (DP; double positive), expressing typical ...
ORGANISM(S): Homo sapiens 
2015-08-31 | E-GEOD-66972 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of heptatocytes from mice given a high-copper diet
In order to study the physiological consequences of a high-copper diet on hepatic gene expression, 6 mM CuCl2 was added to the drinking water for a period of 1 month. After this period, livers of seven control mice and eight copper-treated mice were isolated and were subjected to microarray analysis...
ORGANISM(S): Mus musculus 
2007-06-01 | E-MEXP-745 | biostudies-arrayexpress
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